4m6w: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===Crystal structure of the C-terminal segment of FANCM in complex with FAAP24===

The entry ~~4m6w is ON HOLD~~

==Disease==

[[http://www.uniprot.org/uniprot/FANCM_HUMAN FANCM_HUMAN]] Fanconi anemia. The disease is caused by mutations affecting the gene represented in this entry.

~~Authors~~: ~~Yang~~, H., ~~Zhang, T~~., ~~Tong, L~~., ~~Ding, J~~.

==Function==

[[http://www.uniprot.org/uniprot/FANCM_HUMAN FANCM_HUMAN]] ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair. Binds to ssDNA but not to dsDNA. Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions.<ref>PMID:16116422</ref> <ref>PMID:16116434</ref> [REFERENCE:7][REFERENCE:8] [[http://www.uniprot.org/uniprot/FAP24_HUMAN FAP24_HUMAN]] Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA.

~~Description~~: ~~Crystal structure of the C~~-~~terminal segment of FANCM in complex with FAAP24~~

==About this Structure==

[[4m6w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M6W OCA].

==Reference==

[[Category: Homo sapiens]]

[[Category: RNA helicase]]

[[Category: Ding, J.]]

[[Category: Tong, L.]]

[[Category: Yang, H.]]

[[Category: Zhang, T.]]

[[Category: Dna binding protein]]

[[Category: Dna repair]]

[[Category: Faap24]]

[[Category: Fancm]]

[[Category: Fanconi anemia]]

[[Category: Xpf/mus81]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4m6w|  PDB=4m6w  |  SCENE=  }}
+===Crystal structure of the C-terminal segment of FANCM in complex with FAAP24===
+{{ABSTRACT_PUBMED_24003026}}
-The entry 4m6w is ON HOLD
+==Disease==
+[[http://www.uniprot.org/uniprot/FANCM_HUMAN FANCM_HUMAN]] Fanconi anemia. The disease is caused by mutations affecting the gene represented in this entry.
-Authors: Yang, H., Zhang, T., Tong, L., Ding, J.
+==Function==
+[[http://www.uniprot.org/uniprot/FANCM_HUMAN FANCM_HUMAN]] ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair. Binds to ssDNA but not to dsDNA. Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions.<ref>PMID:16116422</ref> <ref>PMID:16116434</ref> [REFERENCE:7][REFERENCE:8] [[http://www.uniprot.org/uniprot/FAP24_HUMAN FAP24_HUMAN]] Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA.
-Description: Crystal structure of the C-terminal segment of FANCM in complex with FAAP24
+==About this Structure==
+[[4m6w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M6W OCA].
+==Reference==
+<ref group="xtra">PMID:024003026</ref><references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: RNA helicase]]
+[[Category: Ding, J.]]
+[[Category: Tong, L.]]
+[[Category: Yang, H.]]
+[[Category: Zhang, T.]]
+[[Category: Dna binding protein]]
+[[Category: Dna repair]]
+[[Category: Faap24]]
+[[Category: Fancm]]
+[[Category: Fanconi anemia]]
+[[Category: Xpf/mus81]]