3wa4: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Grb2 SH2 domain/CD28-derived peptide complex===

~~The entry 3wa4 is ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/GRB2_HUMAN GRB2_HUMAN]] Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref> Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref> [[http://www.uniprot.org/uniprot/CD28_HUMAN CD28_HUMAN]] Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.

~~Authors~~: ~~Higo, K~~.~~, Oda, M~~.~~, Ito, N~~.

==About this Structure==

[[3wa4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WA4 OCA].

~~Description~~: Grb2 ~~SH2~~ domain~~/CD28-derived peptide complex~~

==Reference==

[[Category: Higo, K.]]

[[Category: Ito, N.]]

[[Category: Oda, M.]]

[[Category: Grb2 sh2 domain]]

[[Category: Signaling protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_3wa4|  PDB=3wa4  |  SCENE=  }}
+===Grb2 SH2 domain/CD28-derived peptide complex===
+{{ABSTRACT_PUBMED_24098653}}
-The entry 3wa4 is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/GRB2_HUMAN GRB2_HUMAN]] Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref>   Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref>  [[http://www.uniprot.org/uniprot/CD28_HUMAN CD28_HUMAN]] Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.
-Authors: Higo, K., Oda, M., Ito, N.
+==About this Structure==
+[[3wa4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WA4 OCA].
-Description: Grb2 SH2 domain/CD28-derived peptide complex
+==Reference==
+<ref group="xtra">PMID:024098653</ref><references group="xtra"/><references/>
+[[Category: Higo, K.]]
+[[Category: Ito, N.]]
+[[Category: Oda, M.]]
+[[Category: Grb2 sh2 domain]]
+[[Category: Signaling protein]]