4npl: Difference between revisions
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{{STRUCTURE_4npl| PDB=4npl | SCENE= }} | {{STRUCTURE_4npl| PDB=4npl | SCENE= }} | ||
===Crystal structure of Zebrafish ALKBH5 in complex with alpha-ketoglutarate=== | ===Crystal structure of Zebrafish ALKBH5 in complex with alpha-ketoglutarate=== | ||
{{ABSTRACT_PUBMED_24561204}} | |||
==Function== | ==Function== | ||
| Line 7: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
[[4npl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NPL OCA]. | [[4npl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NPL OCA]. | ||
==Reference== | |||
<ref group="xtra">PMID:024561204</ref><references group="xtra"/><references/> | |||
[[Category: Chen, W.]] | [[Category: Chen, W.]] | ||
[[Category: He, C.]] | [[Category: He, C.]] | ||
[[Category: Zhang, L.]] | [[Category: Zhang, L.]] | ||
[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||
Revision as of 07:49, 2 April 2014
Crystal structure of Zebrafish ALKBH5 in complex with alpha-ketoglutarate
Template:ABSTRACT PUBMED 24561204
Function
[ALKB5_DANRE] Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m(6)A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Requires molecular oxygen, alpha-ketoglutarate and iron (By similarity).
About this Structure
4npl is a 2 chain structure. Full crystallographic information is available from OCA.
Reference
- Chen W, Zhang L, Zheng G, Fu Y, Ji Q, Liu F, Chen H, He C. Crystal structure of the RNA demethylase ALKBH5 from zebrafish. FEBS Lett. 2014 Mar 18;588(6):892-8. doi: 10.1016/j.febslet.2014.02.021. Epub, 2014 Feb 20. PMID:24561204 doi:https://dx.doi.org/10.1016/j.febslet.2014.02.021
