4ei6: Difference between revisions
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[[ | ==Structure of XV19 Valpha1-Vbeta16 Type-II Natural Killer T cell receptor== | ||
<StructureSection load='4ei6' size='340' side='right' caption='[[4ei6]], [[Resolution|resolution]] 1.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4ei6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EI6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EI6 FirstGlance]. <br> | |||
</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ei5|4ei5]]</td></tr> | |||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ei6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ei6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ei6 RCSB], [http://www.ebi.ac.uk/pdbsum/4ei6 PDBsum]</span></td></tr> | |||
<table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Natural killer T cells (NKT cells) are divided into type I and type II subsets on the basis of differences in their T cell antigen receptor (TCR) repertoire and CD1d-antigen specificity. Although the mode by which type I NKT cell TCRs recognize CD1d-antigen has been established, how type II NKT cell TCRs engage CD1d-antigen is unknown. Here we provide a basis for how a type II NKT cell TCR, XV19, recognized CD1d-sulfatide. The XV19 TCR bound orthogonally above the A' pocket of CD1d, in contrast to the parallel docking of type I NKT cell TCRs over the F' pocket of CD1d. At the XV19 TCR-CD1d-sulfatide interface, the TCRalpha and TCRbeta chains sat centrally on CD1d, where the malleable CDR3 loops dominated interactions with CD1d-sulfatide. Accordingly, we highlight the diverse mechanisms by which NKT cell TCRs can bind CD1d and account for the distinct antigen specificity of type II NKT cells. | |||
Recognition of CD1d-sulfatide mediated by a type II natural killer T cell antigen receptor.,Patel O, Pellicci DG, Gras S, Sandoval-Romero ML, Uldrich AP, Mallevaey T, Clarke AJ, Le Nours J, Theodossis A, Cardell SL, Gapin L, Godfrey DI, Rossjohn J Nat Immunol. 2012 Jul 22. doi: 10.1038/ni.2372. PMID:22820603<ref>PMID:22820603</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
==See Also== | |||
*[[T-cell receptor|T-cell receptor]] | |||
== | == References == | ||
[[ | <references/> | ||
__TOC__ | |||
== | </StructureSection> | ||
< | [[Category: Lk3 transgenic mice]] | ||
[[Category: | |||
[[Category: Patel, O.]] | [[Category: Patel, O.]] | ||
[[Category: Rossjohn, J.]] | [[Category: Rossjohn, J.]] | ||
[[Category: Immune system]] | [[Category: Immune system]] | ||
[[Category: Natural killer t cell receptor]] | [[Category: Natural killer t cell receptor]] | ||
Revision as of 09:10, 11 June 2014
Structure of XV19 Valpha1-Vbeta16 Type-II Natural Killer T cell receptor
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