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[[Image:3co8.png|left|200px]]
==Crystal structure of alanine racemase from Oenococcus oeni==
<StructureSection load='3co8' size='340' side='right' caption='[[3co8]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3co8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Oenococcus_oeni_psu-1 Oenococcus oeni psu-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CO8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CO8 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">OEOE_0162 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=203123 Oenococcus oeni PSU-1])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alanine_racemase Alanine racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.1 5.1.1.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3co8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3co8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3co8 RCSB], [http://www.ebi.ac.uk/pdbsum/3co8 PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/3co8 TOPSAN]</span></td></tr>
</table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/co/3co8_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structure of alanine racemase from Oenococcus oeni has been determined at 1.7 A resolution using the single-wavelength anomalous dispersion (SAD) method and selenium-labelled protein. The protein exists as a symmetric dimer in the crystal, with both protomers contributing to the two active sites. Pyridoxal 5'-phosphate, a cofactor, is bound to each monomer and forms a Schiff base with Lys39. Structural comparison of alanine racemase from O. oeni (Alr) with homologous family members revealed similar domain organization and cofactor binding.


{{STRUCTURE_3co8|  PDB=3co8  |  SCENE=  }}
Structure of alanine racemase from Oenococcus oeni with bound pyridoxal 5'-phosphate.,Palani K, Burley SK, Swaminathan S Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jan 1;69(Pt 1):15-9. doi: , 10.1107/S1744309112047276. Epub 2012 Dec 25. PMID:23295479<ref>PMID:23295479</ref>


===Crystal structure of alanine racemase from Oenococcus oeni===
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>


{{ABSTRACT_PUBMED_23295479}}
==See Also==
 
*[[Alanine racemase|Alanine racemase]]
==About this Structure==
== References ==
[[3co8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Oenococcus_oeni_psu-1 Oenococcus oeni psu-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CO8 OCA].
<references/>
__TOC__
</StructureSection>
[[Category: Alanine racemase]]
[[Category: Alanine racemase]]
[[Category: Oenococcus oeni psu-1]]
[[Category: Oenococcus oeni psu-1]]
[[Category: Burley, S K.]]
[[Category: Palani, K]]
[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics.]]
[[Category: Palani, K.]]
[[Category: Swaminathan, S.]]
[[Category: 11082i]]
[[Category: Alanine racemase]]
[[Category: Isomerase]]
[[Category: New york sgx research center for structural genomic]]
[[Category: Nysgxrc]]
[[Category: Plp]]
[[Category: Plp]]
[[Category: Protein structure initiative ii]]
[[Category: Psi-ii]]
[[Category: Pyridoxal phosphate]]
[[Category: Pyridoxal phosphate]]
[[Category: Structural genomic]]
[[Category: Tim barrel]]

Revision as of 11:23, 6 November 2014

Crystal structure of alanine racemase from Oenococcus oeni

3co8, resolution 1.70Å

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