Importin

spinqualitylabelsall models Structure of yeast importinα NLS-binding domain (grey) complex with nucleoplasmin peptide (green) (PDB code 1ee5). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Importins (IPO) mediate the import of cellular proteins into the nucleus by binding to the nuclear localization signal (NLS). IPO has 2 subunits: α and β. IPO-α is an adaptor protein which binds the NLS. Proteins can contain one or two NLS motifs. IPO-α contains several armadillo repeats with two NLS-binding sites and an IPO-β binding site (IBB). IPO-β contains 19 HEAT repeats. Many nuclear proteins contain Phe-Gly sequences which can bind to HEAT repeats and thus be transported.

3D structures of importin

Updated on 27-November-2014

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• IPO-α
  • 1ial – mIPO residues 44-496 – mouse
    
  • 1bk5 – yIPO NLS-binding domain - yeast
    
• IPO-α complex with NLS peptide
  • 1ejl – mIPO NLS-binding domain + SV40 large T antigen
    
  • 1ejy – mIPO NLS-binding domain + nucleoplasmin
    
  • 2ynr – mIPO NLS-binding domain + B54NLS
    
  • 1bk6 – yIPO NLS-binding domain + SV40 large T antigen
    
  • 1ee4 – yIPO NLS-binding domain (mutant) + c-Myc
    
  • 1ee5 – yIPO NLS-binding domain (mutant) + nucleoplasmin
    
  • 1un0, 2c1t – yIPO NLS-binding domain (mutant) + Nup2
    
• IPO-α complex with protein
  • 1wa5 – yIPO NLS-binding domain + GTPase Ran + IPO-α re-exporter
    
• IPO-α 1 complex with NLS peptide
  • 4mz5, 4mz6 – mIPO NLS-binding domain + dUTPase
    
  • 4oih – mIPO NLS-binding domain + guanine nucleotide exchange factor SRM1
    
• IPO-α 1 complex with protein
  • 2jdq – hIPO NLS-binding domain + polymerase basic protein 2 C terminal
    
  • 3tj3 – hIPO NLS-binding domain + Nup50 N terminal
    
  • 2jdq – hIPO NLS-binding domain + telomerase reverse transcriptase peptide
    
• IPO-α 2
  • 3tpo – mIPO
    
  • 1iq1 – mIPO NLS-binding + autoinhibitory peptide domains
    
  • 4e4v – hIPO NLS-binding domain (mutant) - human
    
• IPO-α 2 complex with NLS peptide
  • 1pjm – mIPO NLS-binding domain + retinoblastoma-associated protein
    
  • 1pjn – mIPO NLS-binding domain + histone-binding protein N1/N2
    
  • 1q1s, 1q1t – mIPO NLS-binding domain + SV40 large T antigen
    
  • 1y2a, 3q5u – mIPO NLS-binding domain + phospholipid scramblase
    
  • 2c1m – mIPO NLS-binding domain + Nup50
    
  • 3btr – mIPO NLS-binding domain + androgen receptor
    
  • 3knd – mIPO NLS-binding domain + targeting protein for KXLP2
    
  • 3l3q – mIPO NLS-binding domain + library peptide
    
  • 3oqs – mIPO NLS-binding domain + CLIC4
    
  • 3rz9 – mIPO NLS-binding domain + KU80
    
  • 3rzx – mIPO NLS-binding domain + KU70
    
  • 3tpm – mIPO NLS-binding domain + MAL
    
  • 3ve6 – mIPO NLS-binding domain + Venezuelan equine encephalitis virus
    
  • 3uvu – mIPO NLS-binding domain + flap endonuclease
    
  • 3ukw, 3ukx – mIPO NLS-binding domain + BIMAX
    
  • 3uky, 3ukz, 3ul0 – mIPO NLS-binding domain + nuclear CAP-binding protein
    
  • 3ul1 – mIPO NLS-binding domain + nucleoplasmin
    
  • 4htv – mIPO NLS-binding domain + capsid protein
    
  • 4ba3 – mIPO NLS-binding domain + A89NLS
    
  • 3zio, 3zip, 3ziq, 3zir – mIPO NLS-binding domain + minor site-specific NLS
    
  • 3zin – mIPO NLS-binding domain + nucleolar RNA helicase
    
• IPO-α 2 complex with protein
  • 3fex, 3fey – mIPO NLS-binding domain + nuclear CAP-binding protein
    
• IPO-β 1
  • 3nd2 – yIPO
    
  • 1gcj – mIPO N terminal
    
• IPO-β 1 complex with protein
  • 1qgx, 1qgr – hIPO + IPO-α 2 IBB domain
    
  • 1ibr – hIPO + GTPase Ran
    
  • 2bku, 3ea5 – yIPO + GTPase Ran
    
  • 1f59, 1o6p, 1o6o – hIPO + FXFG nucleoporin repeats
    
  • 1m5n – hIPO HEAT repeats 1-11 + parathyroid hormone-related protein NLS peptide
    
  • 2p8q, 2q5d, 2qna, 3lww – hIPO + RNA U transporter N terminal
    
  • 1qgr, 3w5k – hIPO + zinc finger protein SNAI1
    
  • 2bpt – yIPO + Nup1
    
  • 1ukl – mIPO + SREBP-2
    
• IPO-β 2 (Transportin 1)
  • 2z5j, 2qmr – hIPO
    
• IPO-β 2 complex with protein
  • 2h4m, 2ot8, 2z5n – hIPO + hnRNP peptide
    
  • 2z5k, 2z5m – hIPO + nuclear RNA export factor peptide
    
  • 2z5o – hIPO + JKTBP peptide
    
  • 4fdd, 4jlq, 4oo6 – hIPO + RNA binding protein peptide
    
  • 4fq3 – hIPO + FUS peptide
    
• IPO-13
  • 2x19 – hIPO + GTPase Ran
    
  • 2xwu – hIPO + UBC9
    
  • 3zjy – hIPO + GTPase Ran + EIF-1A
    

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Michal Harel, Joel L. Sussman