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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|


===Nitrate/nitrite RR===
*Nitrate/nitrite response regulator


[[1rnl]], [[1a04]] – EcNarL – ''Escherichia coli''<br/ >
**[[1rnl]], [[1a04]] – EcNarL – ''Escherichia coli''<br/ >
[[1je8]], [[1zg1]], [[1zg5]] – EcNarL DNA-binding domain + DNA
**[[1je8]], [[1zg1]], [[1zg5]] – EcNarL DNA-binding domain + DNA


===Sporulation RR===
*Sporulation response regulator


[[1srr]], [[2jvi]], [[2jvj]], [[2jvk]] – BsSpo0F (mutant) – ''Bacillus subtilis''<br/ >
**[[1srr]], [[2jvi]], [[2jvj]], [[2jvk]] – BsSpo0F (mutant) – ''Bacillus subtilis''<br/ >
[[1nat]] - BsSpo0F<br/ >
**[[1nat]] - BsSpo0F<br/ >
[[3q15]] - BsSpo0F + RR aspartate phosphatase<br/ >
**[[3q15]] - BsSpo0F + RR aspartate phosphatase<br/ >
[[1ixm]] - BsSpo0B<br/ >
**[[1ixm]] - BsSpo0B<br/ >
[[1fc3]] – GsSpo0A trans-activation domain – ''Geobacillus stearothermophilus''<br />
**[[1fc3]] – GsSpo0A trans-activation domain – ''Geobacillus stearothermophilus''<br />
[[1dz3]], [[1qmp]] - GsSpo0A reciever domain
**[[1dz3]], [[1qmp]] - GsSpo0A reciever domain


===DNA-binding RR===
*DNA-binding response regulator


[[1kgs]] – TmDrrD – ''Thermotoga maritima''<br/ >
**[[1kgs]] – TmDrrD – ''Thermotoga maritima''<br/ >
[[3nnn]] – TmDrrD receiver domain + BeF3<BR/ >
**[[3nnn]] – TmDrrD receiver domain + BeF3<BR/ >
[[1p2f]] – TmDrrB<br/ >
**[[1p2f]] – TmDrrB<br/ >
[[3nns]] - TmDrrB receiver domain + BeF3<BR/ >
**[[3nns]] - TmDrrB receiver domain + BeF3<BR/ >
[[1nxo]], [[1nxp]], [[1nxs]], [[1nxt]], [[1nxv]], [[1nxw]], [[1nxx]] – SpMicArec receiver domain – ''Streptococcus pneumonia''<br/ >
**[[1nxo]], [[1nxp]], [[1nxs]], [[1nxt]], [[1nxv]], [[1nxw]], [[1nxx]] – SpMicArec receiver domain – ''Streptococcus pneumonia''<br/ >
[[2gwr]] - MtMtrA – ''Mycobacterium tuberculosis''<br/ >
**[[2gwr]] - MtMtrA – ''Mycobacterium tuberculosis''<br/ >
[[2hwv]] – VicR C terminal – ''Enterococcus faecalis''<br/ >
**[[2hwv]] – VicR C terminal – ''Enterococcus faecalis''<br/ >
[[2qsj]] – LuxR – ''Silicibbacter pomeroyi''<br/ >
**[[2qsj]] – LuxR – ''Silicibbacter pomeroyi''<br/ >
[[3cnb]], [[3eqz]] – MerR receiver domain – ''Colwellia psychrerythraea''<br/ >
**[[3cnb]], [[3eqz]] – MerR receiver domain – ''Colwellia psychrerythraea''<br/ >
[[2rnj]] – SaVraR DNA-binding domain – ''Staphylococcus aureus'' – NMR<br/ >
**[[2rnj]] – SaVraR DNA-binding domain – ''Staphylococcus aureus'' – NMR<br/ >
[[2zxj]] - SaWalR DNA-binding domain<br/ >
**[[2zxj]] - SaWalR DNA-binding domain<br/ >
[[4gvp]] – SaVraR<br />
**[[4gvp]] – SaVraR<br />
[[4if4]] – SaVraR + Mg + BeF3<br />
**[[4if4]] – SaVraR + Mg + BeF3<br />
[[3q9s]] – DrRR receiver domain – ''Deinococcus radiodurans''<br/ >
**[[3q9s]] – DrRR receiver domain – ''Deinococcus radiodurans''<br/ >
[[3q9v]] - DrRR C terminal<br />
**[[3q9v]] - DrRR C terminal<br />
[[3rjp]] - RR DNA -binding domain – ''Streptococcus pyogenes''<br />
**[[3rjp]] - RR DNA -binding domain – ''Streptococcus pyogenes''<br />


===Cyanobacterial phytochrome RR===
*Cyanobacterial phytochrome response regulator


[[1i3c]] – SyRcp1 – ''Synechocystis''<br/ >
**[[1i3c]] – SyRcp1 – ''Synechocystis''<br/ >
[[1jlk]] – SyRcp1 + Mn<br/ >
**[[1jlk]] – SyRcp1 + Mn<br/ >
[[1k66]] – ToRcpB – ''Tolypothrix''<br/ >
**[[1k66]] – ToRcpB – ''Tolypothrix''<br/ >
[[1k68]] – ToRcpB
**[[1k68]] – ToRcpB


===Phosphatase synthesis RR===
*Phosphatase synthesis response regulator


[[1mvo]] – BsPhoP receiver domain<br/ >
**[[1mvo]] – BsPhoP receiver domain<br/ >
[[2jb9]], [[2jba]] – EcPhoB (mutant) <br/ >
**[[2jb9]], [[2jba]] – EcPhoB (mutant) <br/ >
[[2pmu]] – MtPhoP DNA-binding domain
**[[2pmu]] – MtPhoP DNA-binding domain


===Polar differentiation RR===
*Polar differentiation response regulator


[[1m5t]], [[1m5u]] – CvDivK – ''Caulobacter vibrioides''<br/ >
**[[1m5t]], [[1m5u]] – CvDivK – ''Caulobacter vibrioides''<br/ >
[[1mav]], [[1mb0]], [[1mb3]] – CvDivK + cation
**[[1mav]], [[1mb0]], [[1mb3]] – CvDivK + cation


===Photosynthetic apparatus RR===
*Photosynthetic apparatus response regulator


[[1umq]] – PrrA DNA-binding domain – ''Rhodobacter sphaeroides'' – NMR<br/ >
**[[1umq]] – PrrA DNA-binding domain – ''Rhodobacter sphaeroides'' – NMR<br/ >
[[1ys6]] – MtPrrA <br/ >
**[[1ys6]] – MtPrrA <br/ >
[[1ys7]] – MtPrrA + Mg
**[[1ys7]] – MtPrrA + Mg


===Redox RR===
*Redox response regulator


[[1xhe]] – EcArcA receiver domain <br/ >
**[[1xhe]] – EcArcA receiver domain <br/ >
[[1xhf]] – EcArcA receiver domain + BeF3<BR/ >
**[[1xhf]] – EcArcA receiver domain + BeF3<BR/ >
[[2y79]] – MtDevs GAF domain (mutant)<br />
**[[2y79]] – MtDevs GAF domain (mutant)<br />
[[3zxo]] - MtDevs ATP-binding domain (mutant)<br />
**[[3zxo]] - MtDevs ATP-binding domain (mutant)<br />


===Social motility RR===
*Social motility response regulator


[[2gkg]], [[2i6f]] – MxFrzS receiver domain – ''Myxococcus xanthus'' <br/ >
**[[2gkg]], [[2i6f]] – MxFrzS receiver domain – ''Myxococcus xanthus'' <br/ >
[[2nt3]], [[2nt4]] - MxFrzS receiver domain (mutant)
**[[2nt3]], [[2nt4]] - MxFrzS receiver domain (mutant)


===Stalked-cell differentiation RR===
*Stalked-cell differentiation response regulator


[[2v0n]] – CvPleD + GMP + GTP<br/ >
**[[2v0n]] – CvPleD + GMP + GTP<br/ >
[[2wb4]], [[1w25]] - CvPleD + GMP
**[[2wb4]], [[1w25]] - CvPleD + GMP


===Hypoxia RR===
*Hypoxia response regulator


[[3c3w]], [[1zlj]] – MtDosR<br/ >
**[[3c3w]], [[1zlj]] – MtDosR<br/ >
[[3c57]] – MtDosR C terminal<br />
**[[3c57]] – MtDosR C terminal<br />
[[1zlk]] – MtDosR C terminal + DNA<br />
**[[1zlk]] – MtDosR C terminal + DNA<br />
[[3zxo]] – MtDost ATP-binding domain<br />
**[[3zxo]] – MtDost ATP-binding domain<br />


===Transcriptional RR===
*Transcriptional response regulator


[[2zwm]] – BsYycF receiver domain<br/ >
**[[2zwm]] – BsYycF receiver domain<br/ >
[[3ulq]] – BsComA DNA-binding domain + RR aspartate phosphatase<br />
**[[3ulq]] – BsComA DNA-binding domain + RR aspartate phosphatase<br />
[[2pkx]] – EcPhoP regulatory domain<br />
**[[2pkx]] – EcPhoP regulatory domain<br />
[[3nhz]] – MtMtra N terminal<br />
**[[3nhz]] – MtMtra N terminal<br />


===Stress RR===
*Stress response regulator


[[3n0r]] – CVPhyR
**[[3n0r]] – CVPhyR


===Chemotaxis RR===
*Chemotaxis response regulator


[[3t8y]] - EcCheB<br />
**[[3t8y]] - EcCheB<br />
[[1mih]], [[1jbe]] – EcCheY<br />
**[[1mih]], [[1jbe]] – EcCheY<br />
[[1p6q]] – SmCheY2 - ''Sinorhizobium meliloti''<br />
**[[1p6q]] – SmCheY2 - ''Sinorhizobium meliloti''<br />
[[1p6u]] – SmCheY2 + BeF3<br />
**[[1p6u]] – SmCheY2 + BeF3<br />
[[3hzh]] – CheY-3 + CheX – ''Borrelia burgdorferi''<br />
**[[3hzh]] – CheY-3 + CheX – ''Borrelia burgdorferi''<br />
[[1u0s]] – TmCheY + CheA<br />
**[[1u0s]] – TmCheY + CheA<br />
[[2chy]] – CheY – ''Salmonella typhimurium''
**[[2chy]] – CheY – ''Salmonella typhimurium''


===CheY-like RR===
*CheY-like response regulator


[[3snk]] – RR – ''Mesorhizobium loti''<br/ >
**[[3snk]] – RR – ''Mesorhizobium loti''<br/ >
[[3cg4]], [[3crn]] - RR receiver domain – ''Methanospirillum hungatei''<br/ >
**[[3cg4]], [[3crn]] - RR receiver domain – ''Methanospirillum hungatei''<br/ >
[[3i42]] – RR receiver domain – ''Methylobacter flagellates''<br />
**[[3i42]] – RR receiver domain – ''Methylobacter flagellates''<br />
[[3bre]] – PaRR – ''Pseudomonas aeruginosa''<br/ >
**[[3bre]] – PaRR – ''Pseudomonas aeruginosa''<br/ >


===Two-component RR===
*Two-component response regulator


[[2lpm]] – SmRR  
**[[2lpm]] – SmRR  


===Unspecified RR receiver domain===
*Unspecified response regulator receiver domain


[[2a9o]], [[2a9p]], [[2a9q]] – SpRR + Mn + BeF3<BR/ >
**[[2a9o]], [[2a9p]], [[2a9q]] – SpRR + Mn + BeF3<BR/ >
[[2a9r]] – SpRR + phosphate + Mg<br/ >
**[[2a9r]] – SpRR + phosphate + Mg<br/ >
[[2pln]] – HP1043 – ''Helicobacter pylori''<br/ >
**[[2pln]] – HP1043 – ''Helicobacter pylori''<br/ >
[[2qr3]] – RR – ''Bacteroides fragilis''<br/ >
**[[2qr3]] – RR – ''Bacteroides fragilis''<br/ >
[[2qxy]] – TmRR <br/ >
**[[2qxy]] – TmRR <br/ >
[[2qzj]] – RR – ''Clostridium difficile''<br/ >
**[[2qzj]] – RR – ''Clostridium difficile''<br/ >
[[3kht]] – RR – ''Hahella chejuensis''<br/ >
**[[3kht]] – RR – ''Hahella chejuensis''<br/ >
[[3c3m]] – RR – ''Methanoculleus marisnigri''<br/ >
**[[3c3m]] – RR – ''Methanoculleus marisnigri''<br/ >
[[3cz5]] – RR – ''Aurantimonas''<br/ >
**[[3cz5]] – RR – ''Aurantimonas''<br/ >
[[3heb]] - RR – ''Rhodospirillum rubrum''<br/ >
**[[3heb]] - RR – ''Rhodospirillum rubrum''<br/ >
[[3lte]] – RR – ''Bermanella marisrubri''<br/ >
**[[3lte]] – RR – ''Bermanella marisrubri''<br/ >
[[3jte]], [[3lua]] – RR – ''Clostridium thermocellum''<br />
**[[3jte]], [[3lua]] – RR – ''Clostridium thermocellum''<br />
[[4e7o]] – SpRR<br />
**[[4e7o]] – SpRR<br />
[[4e7p]] – SpRR + BeF3<br />
**[[4e7p]] – SpRR + BeF3<br />
[[2b4a]] – RR Bh3024 – ''Bacillus halodurans''<br />
**[[2b4a]] – RR Bh3024 – ''Bacillus halodurans''<br />


===Unspecified RR===
*Unspecified response regulator


[[1yio]], [[1zn2]] – StyR – ''Pseudomonas fluorescens''<br/ >
**[[1yio]], [[1zn2]] – StyR – ''Pseudomonas fluorescens''<br/ >
[[3a0u]], [[3a10]] – TmTrrA + Mg + BeF3<BR/ >
**[[3a0u]], [[3a10]] – TmTrrA + Mg + BeF3<BR/ >
[[2qvg]] – RR – ''Legionella pneumophila''<br/ >
**[[2qvg]] – RR – ''Legionella pneumophila''<br/ >
[[3gl9]] - TmRR<br/ >
**[[3gl9]] - TmRR<br/ >
[[4hye]] – SpRR<br />
**[[4hye]] – SpRR<br />
[[2zay]] – RR – ''Desulfuromonas acetoxidans''<br/ >
**[[2zay]] – RR – ''Desulfuromonas acetoxidans''<br/ >
[[2rdm]] – RR (mutant) – ''Sinorhizobium medicae''<br/ >
**[[2rdm]] – RR (mutant) – ''Sinorhizobium medicae''<br/ >
[[3hdv]] – RR – ''Pseudomonas putida''<br/ >
**[[3hdv]] – RR – ''Pseudomonas putida''<br/ >
[[3i5a]] – PsWspR – ''Pseudomonas syringae''<br/ >
**[[3i5a]] – PsWspR – ''Pseudomonas syringae''<br/ >
[[3ilh]] – RR – ''Cytophaga hutchinsonii''<br/ >
**[[3ilh]] – RR – ''Cytophaga hutchinsonii''<br/ >
[[3i5b]] – PaWspR GGDEF domain<br/ >
**[[3i5b]] – PaWspR GGDEF domain<br/ >
[[3i5c]] – PaWspR GGDEF domain/GCN4 leucine zipper<br/ >
**[[3i5c]] – PaWspR GGDEF domain/GCN4 leucine zipper<br/ >
[[3ljx]] – McMmoQ – ''Methylococcus capsulatus''<br/ >
**[[3ljx]] – McMmoQ – ''Methylococcus capsulatus''<br/ >
[[3p3q]] – McMmoQ (mutant) <br/ >
**[[3p3q]] – McMmoQ (mutant) <br/ >
[[3lsg]] – RR C terminal – ''Fusobacterium nucleatum''<br/ >
**[[3lsg]] – RR C terminal – ''Fusobacterium nucleatum''<br/ >
[[3nhm]] – MxRR<br/ >
**[[3nhm]] – MxRR<br/ >
[[3m6m]] – XcRpfC REC domain + enoyl-CoA hydratase – ''Xanthomonas campestris''<br/ >
**[[3m6m]] – XcRpfC REC domain + enoyl-CoA hydratase – ''Xanthomonas campestris''<br/ >
[[3qyy]] – XcRR GGDEF domain + GMP<br/ >
**[[3qyy]] – XcRR GGDEF domain + GMP<br/ >
[[3p01]] – RR residues 134-315 – ''Nostoc''<br/ >
**[[3p01]] – RR residues 134-315 – ''Nostoc''<br/ >
[[3rqi]] – RR + phosphate + Ca + citrate – ''Burkholderia pseudomallei''<br/ >
**[[3rqi]] – RR + phosphate + Ca + citrate – ''Burkholderia pseudomallei''<br/ >
[[3kto]] – RR - ''Pseudoalteromonas atlantica''<br />
**[[3kto]] – RR - ''Pseudoalteromonas atlantica''<br />
[[3t0y]] – CvRR anti-anti-σ domain + anti-σ factor NEPR<br />
**[[3t0y]] – CvRR anti-anti-σ domain + anti-σ factor NEPR<br />
[[2oqr]] – MtRR Regx3 <br />
**[[2oqr]] – MtRR Regx3 <br />
[[3sy8]] – PaRR Rocr <br />
**[[3sy8]] – PaRR Rocr <br />
[[4ixa]] – RR Saer DNA-binding domain – ''Staphylococcus epidermidis''<br />
**[[4ixa]] – RR Saer DNA-binding domain – ''Staphylococcus epidermidis''<br />
[[4ml3]], [[4mld]] – SpRR Rec domain (mutant)<br />
**[[4ml3]], [[4mld]] – SpRR Rec domain (mutant)<br />
[[4cbv]] – SpRR (mutant)<br />
**[[4cbv]] – SpRR (mutant)<br />


===RR complex with histidine kinase===
*Response regulator complex with histidine kinase
 
[[3dge]], [[3dgf]] – TmRR + sensor protein<br/ >
[[3a0r]] – TmTrrA (mutant) + sensor protein<br />
[[4jas]], [[4jav]] – TmRR (mutant) + histidine kinase<br />


**[[3dge]], [[3dgf]] – TmRR + sensor protein<br/ >
**[[3a0r]] – TmTrrA (mutant) + sensor protein<br />
**[[4jas]], [[4jav]] – TmRR (mutant) + histidine kinase<br />




}}




Revision as of 10:29, 7 December 2014

Template:STRUCTURE 1kgs

Response regulators (RR) are part of the two-component signal transduction systems which enable bacteria to sense and respond to a wide range of environments. Two-component RR is a complex of histidine kinase (sensor protein SP) and RR. The RR act as phosphorylation-activated switches. Most RR consist of N terminal shich is the signal receiving domain and C terminal which is the DNA-binding domain. RR CheY is a chemotaxis response regulator in bacteria. RR Spo0 is the sporulation response regulator. For details see:
For PleD:

For PhoP:

For photosynthetic apparatus RR:

For WspR RR:

3D Structures of response regulator

Updated on 07-December-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky

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