3rbg: Difference between revisions
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==Crystal structure analysis of Class-I MHC restricted T-cell associated molecule== | |||
<StructureSection load='3rbg' size='340' side='right' caption='[[3rbg]], [[Resolution|resolution]] 2.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3rbg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RBG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RBG FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CRTAM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rbg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rbg RCSB], [http://www.ebi.ac.uk/pdbsum/3rbg PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The members of the immunoglobulin superfamily (IgSF) control innate and adaptive immunity and are prime targets for the treatment of autoimmune diseases, infectious diseases, and malignancies. We describe a computational method, termed the Brotherhood algorithm, which utilizes intermediate sequence information to classify proteins into functionally related families. This approach identifies functional relationships within the IgSF and predicts additional receptor-ligand interactions. As a specific example, we examine the nectin/nectin-like family of cell adhesion and signaling proteins and propose receptor-ligand interactions within this family. Guided by the Brotherhood approach, we present the high-resolution structural characterization of a homophilic interaction involving the class-I MHC-restricted T-cell-associated molecule, which we now classify as a nectin-like family member. The Brotherhood algorithm is likely to have a significant impact on structural immunology by identifying those proteins and complexes for which structural characterization will be particularly informative. | |||
Functional classification of immune regulatory proteins.,Rubinstein R, Ramagopal UA, Nathenson SG, Almo SC, Fiser A Structure. 2013 May 7;21(5):766-76. doi: 10.1016/j.str.2013.02.022. Epub 2013 Apr, 11. PMID:23583034<ref>PMID:23583034</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
== | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Almo, S C | [[Category: Almo, S C]] | ||
[[Category: Fiser, A | [[Category: Fiser, A]] | ||
[[Category: IFN, Atoms-to-Animals:.The Immune Function Network | [[Category: IFN, Atoms-to-Animals:.The Immune Function Network]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: Nathenson, S G | [[Category: Nathenson, S G]] | ||
[[Category: Ramagopal, U A | [[Category: Ramagopal, U A]] | ||
[[Category: Rubinstein, R | [[Category: Rubinstein, R]] | ||
[[Category: Toro, R | [[Category: Toro, R]] | ||
[[Category: Atoms-to-animals: the immune function network]] | [[Category: Atoms-to-animals: the immune function network]] | ||
[[Category: Crtam]] | [[Category: Crtam]] | ||
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[[Category: Igv]] | [[Category: Igv]] | ||
[[Category: Immune system]] | [[Category: Immune system]] | ||
[[Category: Nysgrc]] | [[Category: Nysgrc]] | ||
[[Category: Psi-biology]] | [[Category: Psi-biology]] | ||
Revision as of 11:03, 19 December 2014
Crystal structure analysis of Class-I MHC restricted T-cell associated molecule
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