4h0d: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4h0d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H0D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H0D FirstGlance]. <br> | <table><tr><td colspan='2'>[[4h0d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H0D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H0D FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZZ7:(2R,4S)-2-[(R)-{[(2R)-2-AMINO-2-PHENYLACETYL]AMINO}(CARBOXY)METHYL]-5,5-DIMETHYL-1,3-THIAZOLIDINE-4-CARBOXYLIC+ACID'>ZZ7</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZZ7:(2R,4S)-2-[(R)-{[(2R)-2-AMINO-2-PHENYLACETYL]AMINO}(CARBOXY)METHYL]-5,5-DIMETHYL-1,3-THIAZOLIDINE-4-CARBOXYLIC+ACID'>ZZ7</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3rkj|3rkj]], [[3rkk|3rkk]], [[3sbl|3sbl]], [[3sfp|3sfp]], [[3srx|3srx]], [[4gyq|4gyq]], [[4gyu|4gyu]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3rkj|3rkj]], [[3rkk|3rkk]], [[3sbl|3sbl]], [[3sfp|3sfp]], [[3srx|3srx]], [[4gyq|4gyq]], [[4gyu|4gyu]]</td></tr> | ||
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">blaNDM-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 Klebsiella pneumoniae])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">blaNDM-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 Klebsiella pneumoniae])</td></tr> | ||
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h0d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4h0d RCSB], [http://www.ebi.ac.uk/pdbsum/4h0d PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h0d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4h0d RCSB], [http://www.ebi.ac.uk/pdbsum/4h0d PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN]] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin. | |||
==See Also== | ==See Also== | ||
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[[Category: Beta-lactamase]] | [[Category: Beta-lactamase]] | ||
[[Category: Klebsiella pneumoniae]] | [[Category: Klebsiella pneumoniae]] | ||
[[Category: Babnigg, J | [[Category: Babnigg, J]] | ||
[[Category: Binkowski, T A | [[Category: Binkowski, T A]] | ||
[[Category: Jedrzejczak, R | [[Category: Jedrzejczak, R]] | ||
[[Category: Joachimiak, A | [[Category: Joachimiak, A]] | ||
[[Category: Kim, Y | [[Category: Kim, Y]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: MTBI, Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors | [[Category: MTBI, Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors]] | ||
[[Category: Mire, J | [[Category: Mire, J]] | ||
[[Category: Sacchettini, J | [[Category: Sacchettini, J]] | ||
[[Category: Tesar, C | [[Category: Tesar, C]] | ||
[[Category: Alpha-beta-beta-alpha fold]] | [[Category: Alpha-beta-beta-alpha fold]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
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[[Category: Hydrolase-antibiotics complex]] | [[Category: Hydrolase-antibiotics complex]] | ||
[[Category: Mcsg]] | [[Category: Mcsg]] | ||
[[Category: Mtbi]] | [[Category: Mtbi]] | ||
[[Category: Psi-biology]] | [[Category: Psi-biology]] | ||
[[Category: Structures of mtb proteins conferring susceptibility to known mtb inhibitor]] | [[Category: Structures of mtb proteins conferring susceptibility to known mtb inhibitor]] | ||
Revision as of 01:44, 25 December 2014
New Delhi Metallo-beta-Lactamase-1 Complexed with Mn from Klebsiella pneumoniae
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Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Beta-lactamase
- Klebsiella pneumoniae
- Babnigg, J
- Binkowski, T A
- Jedrzejczak, R
- Joachimiak, A
- Kim, Y
- Structural genomic
- MTBI, Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors
- Mire, J
- Sacchettini, J
- Tesar, C
- Alpha-beta-beta-alpha fold
- Hydrolase
- Hydrolase-antibiotic complex
- Hydrolase-antibiotics complex
- Mcsg
- Mtbi
- Psi-biology
- Structures of mtb proteins conferring susceptibility to known mtb inhibitor
