4m3l: Difference between revisions
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==Crystal Structure of the coiled coil domain of MuRF1== | |||
<StructureSection load='4m3l' size='340' side='right' caption='[[4m3l]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
==Function== | <table><tr><td colspan='2'>[[4m3l]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M3L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M3L FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ddt|3ddt]]</td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IRF, MURF1, RNF28, SMRZ, TRIM63 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m3l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m3l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4m3l RCSB], [http://www.ebi.ac.uk/pdbsum/4m3l PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/TRI63_HUMAN TRI63_HUMAN]] E3 ubiquitin ligase. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.<ref>PMID:11927605</ref> | [[http://www.uniprot.org/uniprot/TRI63_HUMAN TRI63_HUMAN]] E3 ubiquitin ligase. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.<ref>PMID:11927605</ref> | ||
== | ==See Also== | ||
[[ | *[[Ubiquitin protein ligase|Ubiquitin protein ligase]] | ||
== References == | |||
== | <references/> | ||
<references | __TOC__ | ||
[[Category: Franke, B | </StructureSection> | ||
[[Category: Mayans, O | [[Category: Human]] | ||
[[Category: Franke, B]] | |||
[[Category: Mayans, O]] | |||
[[Category: E3 ubiquitin ligase]] | [[Category: E3 ubiquitin ligase]] | ||
[[Category: Ligase]] | [[Category: Ligase]] | ||
[[Category: Sarcoskeleton]] | [[Category: Sarcoskeleton]] | ||
[[Category: Titin]] | [[Category: Titin]] | ||
Revision as of 11:42, 25 December 2014
Crystal Structure of the coiled coil domain of MuRF1
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