4nan: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4nan]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NAN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NAN FirstGlance]. <br> | <table><tr><td colspan='2'>[[4nan]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NAN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NAN FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2JM:2-BROMO-6-(3,4,5-TRIBROMO-1H-PYRROL-2-YL)PHENOL'>2JM</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2JM:2-BROMO-6-(3,4,5-TRIBROMO-1H-PYRROL-2-YL)PHENOL'>2JM</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1w77|1w77]], [[2yc5|2yc5]], [[1ini|1ini]], [[4nai|4nai]], [[4nak|4nak]], [[4nal|4nal]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1w77|1w77]], [[2yc5|2yc5]], [[1ini|1ini]], [[4nai|4nai]], [[4nak|4nak]], [[4nal|4nal]]</td></tr> | ||
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">At2g02500, ISPD, MCT, MECT, MEPCT, T8K22.20 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">At2g02500, ISPD, MCT, MECT, MEPCT, T8K22.20 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr> | ||
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2-C-methyl-D-erythritol_4-phosphate_cytidylyltransferase 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.60 2.7.7.60] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2-C-methyl-D-erythritol_4-phosphate_cytidylyltransferase 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.60 2.7.7.60] </span></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nan OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nan RCSB], [http://www.ebi.ac.uk/pdbsum/4nan PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nan OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nan RCSB], [http://www.ebi.ac.uk/pdbsum/4nan PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/ISPD_ARATH ISPD_ARATH]] Enzyme of the plastid non-mevalonate pathway for isoprenoid biosynthesis that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). Is essential for chloroplast development and required for pigments and gibberellins biosynthesis.<ref>PMID:10841550</ref> <ref>PMID:12029484</ref> <ref>PMID:18236010</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Pseudilins: Halogenated, Allosteric Inhibitors of the Non-Mevalonate Pathway Enzyme IspD.,Kunfermann A, Witschel M, Illarionov B, Martin R, Rottmann M, Hoffken HW, Seet M, Eisenreich W, Knolker HJ, Fischer M, Bacher A, Groll M, Diederich F Angew Chem Int Ed Engl. 2014 Jan 20. doi: 10.1002/anie.201309557. PMID:24446431<ref>PMID:24446431</ref> | Pseudilins: Halogenated, Allosteric Inhibitors of the Non-Mevalonate Pathway Enzyme IspD.,Kunfermann A, Witschel M, Illarionov B, Martin R, Rottmann M, Hoffken HW, Seet M, Eisenreich W, Knolker HJ, Fischer M, Bacher A, Groll M, Diederich F Angew Chem Int Ed Engl. 2014 Jan 20. doi: 10.1002/anie.201309557. PMID:24446431<ref>PMID:24446431</ref> | ||
From | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
==See Also== | |||
*[[MEP cytidylyltransferase|MEP cytidylyltransferase]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase]] | [[Category: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase]] | ||
[[Category: Arath]] | [[Category: Arath]] | ||
[[Category: Bacher, A | [[Category: Bacher, A]] | ||
[[Category: Diederich, F | [[Category: Diederich, F]] | ||
[[Category: Eisenreich, W | [[Category: Eisenreich, W]] | ||
[[Category: Fischer, M | [[Category: Fischer, M]] | ||
[[Category: Groll, M | [[Category: Groll, M]] | ||
[[Category: Hoffken, H W | [[Category: Hoffken, H W]] | ||
[[Category: Illarionov, B | [[Category: Illarionov, B]] | ||
[[Category: Knolker, H J | [[Category: Knolker, H J]] | ||
[[Category: Kunfermann, A | [[Category: Kunfermann, A]] | ||
[[Category: Martin, R | [[Category: Martin, R]] | ||
[[Category: Rottmann, M | [[Category: Rottmann, M]] | ||
[[Category: Seet, M | [[Category: Seet, M]] | ||
[[Category: Witschel, M | [[Category: Witschel, M]] | ||
[[Category: Allosteric inhibition]] | [[Category: Allosteric inhibition]] | ||
[[Category: Anti-infective]] | [[Category: Anti-infective]] | ||
Revision as of 14:15, 25 December 2014
Arabidopsis thaliana IspD in complex with tetrabromo-pseudilin
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Proteopedia Page Contributors and Editors (what is this?)
Categories:
- 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
- Arath
- Bacher, A
- Diederich, F
- Eisenreich, W
- Fischer, M
- Groll, M
- Hoffken, H W
- Illarionov, B
- Knolker, H J
- Kunfermann, A
- Martin, R
- Rottmann, M
- Seet, M
- Witschel, M
- Allosteric inhibition
- Anti-infective
- Drug discovery
- Herbicide
- Natural product
- Pseudilin
- Rossmann fold
- Transferase
- Transferase-transferase inhibitor complex
