2jxb: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2jxb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JXB FirstGlance]. <br> | <table><tr><td colspan='2'>[[2jxb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JXB FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CD3E, NCK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CD3E, NCK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jxb RCSB], [http://www.ebi.ac.uk/pdbsum/2jxb PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jxb RCSB], [http://www.ebi.ac.uk/pdbsum/2jxb PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/NCK2_HUMAN NCK2_HUMAN]] Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.<ref>PMID:10026169</ref> <ref>PMID:16835242</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Ng, E | [[Category: Ng, E]] | ||
[[Category: Park, S | [[Category: Park, S]] | ||
[[Category: Reinherz, E L | [[Category: Reinherz, E L]] | ||
[[Category: Sun, Z J | [[Category: Sun, Z J]] | ||
[[Category: Takeuchi, K | [[Category: Takeuchi, K]] | ||
[[Category: Wagner, G | [[Category: Wagner, G]] | ||
[[Category: Yang, H | [[Category: Yang, H]] | ||
[[Category: Cd3epsilon]] | [[Category: Cd3epsilon]] | ||
[[Category: Immunology]] | [[Category: Immunology]] | ||
Revision as of 22:01, 25 December 2014
Structure of CD3epsilon-Nck2 first SH3 domain complex
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