Atlastin: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| Line 7: | Line 7: | ||
== Disease == | == Disease == | ||
Defects in the ATN gene are a cause of the degenerative spinal cord disorder spastic paraplegia type 3. | Defects in the ATN gene are a cause of the degenerative spinal cord disorder spastic paraplegia type 3 and of hereditary sensory neuropathy type 1D. | ||
==3D structures of atlastin== | ==3D structures of atlastin== | ||
Revision as of 10:18, 8 November 2015
<StructureSection load='4ido' size='340' side='right' caption='Structure of human atlastin cytoplasmic domain complex with GDP and AlF4 (PDB code 4ido).' scene=>
Function
Atlastin (ATN) is a GTPase and a Golgi body transmembrane protein. ATN was shown to be required in membrane fusion and ER formation in Drosophila melanogaster.
Disease
Defects in the ATN gene are a cause of the degenerative spinal cord disorder spastic paraplegia type 3 and of hereditary sensory neuropathy type 1D.
3D structures of atlastin
Updated on 08-November-2015
3q5d, 3q5e, 3qnu, 3qof – hATN cytoplasmic domain + GDP – human
4idn – hATN cytoplasmic domain + GNP
4idp – hATN cytoplasmic domain (mutant) + GNP
4ido – hATN cytoplasmic domain + GDP + AlF4
4idq – hATN cytoplasmic domain (mutant) + GDP + AlF4
