CD3: Difference between revisions
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<StructureSection load='1sy6' size='450' side='right' caption='Structure of human CD3 extracellular domain (green) complex with antibody light chain (cyan) and heavy chain (red) (PDB entry [[1sy6]])' scene='55/551236/Cv/1'> | <StructureSection load='1sy6' size='450' side='right' caption='Structure of human CD3 extracellular domain (green) complex with antibody light chain (cyan) and heavy chain (red) (PDB entry [[1sy6]])' scene='55/551236/Cv/1'> | ||
'''CD3''' (or '''Cluster of Differentiation 3''') is a T-cell co-receptor. The CD3 is composed of γ, δ and two ε chains. These 4 chains associate with the T-cell receptor (TCR) and a ζ chain to form an activation signal in T lymphocytes. CD3 assembles as 3 pairs of dimers: εγ, εδ and ζζ. The intracellular domain of CD3 contains a single immunorecetor tyrosine-based activation motif (ITAM). Drugs which bind to CD3 are tested as immunorepressants. | '''CD3''' (or '''Cluster of Differentiation 3''') is a T-cell co-receptor. The CD3 is composed of γ, δ and two ε chains. These 4 chains associate with the T-cell receptor (TCR) and a ζ chain to form an activation signal in T lymphocytes. CD3 assembles as 3 pairs of dimers: εγ, εδ and ζζ. The intracellular domain of CD3 contains a single immunorecetor tyrosine-based activation motif (ITAM). Drugs which bind to CD3 are tested as immunorepressants. | ||
<scene name='55/551236/Cv/2'>Human CD3 extracellular domain complex with antibody light chain and heavy chain</scene> (PDB entry [[1sy6]]).<ref>PMID:15136729</ref> | |||
</StructureSection> | </StructureSection> | ||
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**[[2hac]] – hCD3 transmembrane domain - NMR<BR /> | **[[2hac]] – hCD3 transmembrane domain - NMR<BR /> | ||
}} | }} | ||
== References == | |||
<references/> | |||
[[Category: Topic Page]] | [[Category: Topic Page]] | ||
