CD4: Difference between revisions

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'''CD4''' (or '''Cluster of Differentiation 4''') is a glycoprotein found on the surface of immune cells. CD4 has 4 immunoglobulin (Ig) domains, a transmembrane domain and a cytoplasmic tail domain. D1 and D3 resemble Ig variable domain and D2 and D4 resemble the Ig constant domain. The D1 domain interacts with class II MHC molecules. CD4 helps T-cell receptors (TCR) interact with antigen-presenting cells. The CD4 tail interacts with tyrosine kinase Lck which activates molecular components of the signaling pathway. HIV-1 binds to CD4 initiating conformation changes in its protein gp120 and allowing the entry of HIV-1 to the host T-cell.

'''CD4''' (or '''Cluster of Differentiation 4''') is a glycoprotein found on the surface of immune cells. CD4 has 4 immunoglobulin (Ig) domains, a transmembrane domain and a cytoplasmic tail domain. D1 and D3 resemble Ig variable domain and D2 and D4 resemble the Ig constant domain. The D1 domain interacts with class II MHC molecules. CD4 helps T-cell receptors (TCR) interact with antigen-presenting cells. The CD4 tail interacts with tyrosine kinase Lck which activates molecular components of the signaling pathway. HIV-1 binds to CD4 initiating conformation changes in its protein gp120 and allowing the entry of HIV-1 to the host T-cell.<ref>PMID:8493535</ref>

*<scene name='55/551234/Cv/2'>CD4 with antibody and HIV-1 gp120</scene> ([[2nxy]]).<ref>PMID:17301785</ref>

</StructureSection>

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 <StructureSection load='2nxy' size='450' side='right' caption='Structure of CD4 (green) complex with antibody light chain (pink), heavy chain (yellow), HIV-1 gp120 (cyan), TRIS and hexane-diol (PDB entry [[2nxy]])' scene='55/551234/Cv/1'>
-'''CD4''' (or '''Cluster of Differentiation 4''') is a glycoprotein found on the surface of immune cells.  CD4 has 4 immunoglobulin (Ig) domains, a transmembrane domain and a cytoplasmic tail domain.  D1 and D3 resemble Ig variable domain and D2 and D4 resemble the Ig constant domain.  The D1 domain interacts with class II MHC molecules.  CD4 helps T-cell receptors (TCR) interact with antigen-presenting cells.  The CD4 tail interacts with tyrosine kinase Lck which activates molecular components of the signaling pathway.  HIV-1 binds to CD4 initiating conformation changes in its protein gp120 and allowing the entry of HIV-1 to the host T-cell.
+'''CD4''' (or '''Cluster of Differentiation 4''') is a glycoprotein found on the surface of immune cells.  CD4 has 4 immunoglobulin (Ig) domains, a transmembrane domain and a cytoplasmic tail domain.  D1 and D3 resemble Ig variable domain and D2 and D4 resemble the Ig constant domain.  The D1 domain interacts with class II MHC molecules.  CD4 helps T-cell receptors (TCR) interact with antigen-presenting cells.  The CD4 tail interacts with tyrosine kinase Lck which activates molecular components of the signaling pathway.  HIV-1 binds to CD4 initiating conformation changes in its protein gp120 and allowing the entry of HIV-1 to the host T-cell.<ref>PMID:8493535</ref>
 *<scene name='55/551234/Cv/2'>CD4 with antibody and HIV-1 gp120</scene> ([[2nxy]]).<ref>PMID:17301785</ref>
 </StructureSection>