CD44: Difference between revisions
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<Structure load='2jcq' size='400' frame='true' align='right' caption='Structure of mouse CD44 hyaluronan-binding domain complex with 8-mer HA (PDB entry [[2jcq]])' scene='Insert optional scene name here' /> | <Structure load='2jcq' size='400' frame='true' align='right' caption='Structure of mouse CD44 hyaluronan-binding domain complex with 8-mer HA (PDB entry [[2jcq]])' scene='Insert optional scene name here' /> | ||
== Function == | |||
'''CD44''' is a glycoprotein involved in cell-cell interactions. CD44 is a receptor of hyaluronic acid (HA). CD44 undergoes post-translational modification. Its sialofucosylation changes it to a form which directs migration of stem cells to bone marrow. | '''CD44''' is a glycoprotein involved in cell-cell interactions. CD44 is a receptor of hyaluronic acid (HA). CD44 undergoes post-translational modification. Its sialofucosylation changes it to a form which directs migration of stem cells to bone marrow. | ||
== Relevance == | |||
CD44 is a potential drug target for treatment of malignant neoplasms. Anti-CD44 antibody treatment lowers hyperglycemia and chronic inflammatory diseases. | |||
==3D structures of CD44== | ==3D structures of CD44== | ||
