CD1: Difference between revisions
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'''CD1''' (or '''Cluster of Differentiation 1''') is related to class I MHC molecules. CD1 is expressed on the surface of antigen presenting cells and presents lipid antigens to T cells. There are 3 groups of CD1 differing in their lipid anchoring. Group 1 contains CD1a, CD1b and CD1c. Group 2 contains CD1d. Group 3 contains CD1e. CD1 structure is comprised of a heavy chain with a1, a2 and a3 domains which is non-covalently associated with β-microglobulin. CD1 contains a larger and deeper antigen binding groove than class I MHC molecules.<ref>PMID:17593656</ref> | '''CD1''' (or '''Cluster of Differentiation 1''') is related to class I MHC molecules. CD1 is expressed on the surface of antigen presenting cells and presents lipid antigens to T cells. There are 3 groups of CD1 differing in their lipid anchoring. Group 1 contains CD1a, CD1b and CD1c. Group 2 contains CD1d. Group 3 contains CD1e. CD1 structure is comprised of a heavy chain with a1, a2 and a3 domains which is non-covalently associated with β-microglobulin. CD1 contains a larger and deeper antigen binding groove than class I MHC molecules.<ref>PMID:17593656</ref> | ||
*<scene name='55/551229/Cv/2'>Mouse CD1 extracellular domain with β-microglobulin complex and glycolipid</scene>(PDB entry [[3ilp]]).<ref>PMID:20080535</ref> | *<scene name='55/551229/Cv/2'>Mouse CD1 extracellular domain with β-microglobulin complex and glycolipid</scene> (PDB entry [[3ilp]]).<ref>PMID:20080535</ref> | ||
</StructureSection> | </StructureSection> | ||
