Flavin reductase: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| Line 1: | Line 1: | ||
<StructureSection load='1he2' size='350' side='right' scene='' caption='Human flavin reductase complex with biliverdin IX α and NADP (PDB code [[1he2]]) '> | <StructureSection load='1he2' size='350' side='right' scene='' caption='Human flavin reductase complex with biliverdin IX α and NADP (PDB code [[1he2]]) '> | ||
| Line 15: | Line 14: | ||
FR catalytic reaction is the basis of the therapeutic use of methylene blue or riboflavin in the treatment of methemoglobinemia. Bacterial FR are used to sensitize tumors to drugs. | FR catalytic reaction is the basis of the therapeutic use of methylene blue or riboflavin in the treatment of methemoglobinemia. Bacterial FR are used to sensitize tumors to drugs. | ||
== Structural insights == | |||
The NADP containing active site can accommodate a variety of ligands because the binding is achieved via mainly hydrophobic interactions. | |||
</StructureSection> | </StructureSection> | ||
Revision as of 16:29, 22 January 2016
| ||||||||||||
3D structures of flavin reductase
Updated on 22-January-2016
1qfj – FR – Escherichia coli
1bkj – VhFR + FMN – Vibrio harveyi
2bkj - VhFR + NAD + FMN
1hdo - hFR + NADP - human
1he2 - hFR + biliverdin IX α + NADP
1he3 - hFR + mesobiliverdin IV α + NADP
1he4 - hFR + FMN + NADP
1he5 - hFR + lumichrome + NADP
1rz0 – GtFR + FAD – Geobacillus thermoglucosidasius
1rz1 - GtFR + FAD + NAD
3pft - FR (mutant) + FMN – Mycobacterium goodii
