ATPase

spinqualitylabelsall models An ATPase, Human RuvB-like 1 dodecamer complex with ADP (PDB code 2c9o) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D ATPase is an enzyme which catalyzes the breakdown of ATP into ADP and a phosphate ion. This dephosphorylation releases energy which the enzyme uses to drive other reactions. ATPase types include: F-ATPase - the prime producers of ATP; V-ATPase or Vacuolar-type H+ ATPase couples the energy to proton transport across membranes; A-ATPase are found in archaea. For details see A-ATP Synthase; P-ATPase transport ions; E-ATPase hydrolyze extracellular ATP. MipZ is an ATPase which forms a complex with the chromosome partitioning protein ParB and is responsible for the regulation of FtsZ ring formation. ATPase domains include metal-binding domain (MBD) and nucleotide-binding domain (NBD). For more details see: Cu transporting ATPase are in P(1B)-Type Cu(I) Transporting ATPases ATP7A and ATP7B. Na/K transporting ATPase are in Sodium-Potassium ATPase. H/K transporting ATPase are in Esomeprazole and H+/K+ - ATPase Interaction. Transitional endoplasmic reticulum ATPase are in Valosin Containing Protein D120. Central stalk in F(1)-ATPase is described in A-ATP Synthase. Journal:JSB:1

3D Structures of ATPase

Updated on 12-February-2016

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• F-ATPase
• F1F0 ATPase α subunit
  • A-ATP Synthase - bF1-ATPS+subunit O
    
  • P(1B)-Type Cu(I) Transporting ATPases ATP7A and ATP7B - F1-ATPS – Thermotoga maritima
• F1F0 ATPase β subunit
  • Sodium-Potassium ATPase – EcF1-ATPS membrane domain – Escherichia coli -NMR
    
  • Esomeprazole and H+/K+ - ATPase Interaction – EcF1-ATPS membrane domain + insertase YIDC – Cryo EM
    
  • Valosin Containing Protein D120 – EcF1-ATPS dimerization domain
    
  • A-ATP Synthase - EcF1-ATPS fragment – NMR
    
  • Journal:JSB:1 - F1-ATPS – NMR – tobacco
    
  • 4q4l - F1-ATPS – Burkholderia thailandensis
    
• F1F0 ATPase γ subunit
  • 1wu0 – BsATPS – NMR
    
  • 1a91, 1c0v, 1aty, 1c99 - EcF1-ATPS – NMR
    
  • 2wgm, 1yce – F0-ATPS – Ilyobacter tartaricus
    
  • 2x2v, 4cbk, 4cbj – F0-ATPS – Bacillus pseudofirmus
    
  • 4mjn - F1-ATPS - wheat
    
  • 4bem - F1F0-ATPS – Acetobacterium woodii
    
• F1F0 ATPase δ subunit
  • 1abv – EcF1-ATPS N terminal – NMR
    
• F1F0 ATPase ε subunit
  • 2rq6, 2rq7 - F1-ATPS – Thermosynechococcus elongatus
    
  • 1abv, 1aqt – EcF1-ATPS (mutant)
    
  • 1bsh, 1bsn – EcF1-ATPS – NMR
    
  • 2e5t, 2e5u – BsF1-ATPS C terminal – NMR
    
  • 2e5y – BsF1-ATPS
• F1F0 ATPase α, β subunits
  • [1sky]] – BsF1-ATPS – Bacillus sp. Ps3
• F1F0 ATPase α,γ subunits
  • 1c17 – EcF1-ATPS – NMR
    
• F1F0 ATPase α, δ subunits
  • 2a7u – EcF1-ATPS N termini – NMR
    
• F1F0 ATPase β, δ subunits
  • 2cly – bF1-ATPS + ATPS coupling factor
• F1F0 ATPase γ, ε subunits
  • 1fs0 – EcF1-ATPS
• F1F0 ATPase α, β, γ subunits
  • 1ohh, 2jiz, 4tt3, 4tsf – bF1-ATPS+ IF1 inhibitor – bovine
    
  • 1e1q, 2w6e, 2w6f, 2w6g, 2w6h, 2w6i, 2w6j - bF1-ATPS
    
  • 1e1r - bF1-ATPS+Mg+ADP+AlF4
    
  • 1w0j, 1w0k - bF1-ATPS+BeF3
    
  • 1nbm - bF1-ATPS+nitrobenzofurazan
    
  • 1mab, 2f43 - F1-ATPS – rat
• F1F0 ATPase α,β,γ,δ subunits
  • 1qo1 - yF1-ATPS + protein 9
    
• F1F0 ATPase α,β,γ,ε subunits
  • 1jnv - EcF1-ATPS
    
  • 3oaa – EcF1-ATPS (mutant)
    
  • 2qe7 – F1-ATPS – Bacillus
    
• F1F0 ATPase α, β, γ, δ, ε subunits
  • 4asu, 2jdi, 2jj1, 2jj2 - bF1-ATPS
    
  • 2v7q, 1e79, 2ck3 - bF1-ATPS+inhibitor
    
  • 2xnd, 2xok - bF1-ATPS+ATPS lipid-binding protein
    
  • 2wpd, 2wss - yF1-ATPS+subunit 9+Mg+ADP+ATP - yeast
    
  • 3oe7, 3oee, 3oeh, 3ofn - yF1-ATPS (mutant)
    
  • 3fks, 3zry, 2hld - yF1-ATPS
    
  • 3zia - yF1-ATPS + inhibitor protein
    
  • 3j0j – TtATPS α,β,γ,δ,ε,ζ - Cryo EM
    
  • 1e79 - bF1-ATPS
    
• F1F0 ATPase α,β,γ,δ,ε,9,B,D,6,O subunits
  • 4b2q – yATPase subunits α,β,γ,δ,ε +9,B,D,6,O – Cryo EM
  • 1bmf - bF1-ATPS
    
  • 3dze – bF1-ATPS subunit S
    
  • 1cow - bF1-ATPS+aurovertin B
    
  • 4f4s – yATPase subunit 9 + oligomycin
    
• V-ATPase
• V-ATPase subunit A
  • 3i4l - PhATPS subunit A+AMPPNP
    
  • 3mfy, 3m4y, 3nd8, 3nd9, 3p20, 3qg1, 3qia, 3qjy, 3sdz, 3se0 - PhATPS subunit A (mutant)
    
  • 3i72, 3i73, 3ikj - TtATPS subunit A (mutant)
    
  • 4o1s - ATPS subunit A – Thermoplasma volcanium
    
• V-ATPase subunit B
  • 2c61 - MmATPS subunit B – Methanosarcina mazei
    
  • 2rkw, 3b2q, 3ssa, 3tgw, 3tiv - MmATPS subunit B (mutant)
    
  • 3dsr - MmATPS subunit B+ADP
    
  • 3eiu - MmATPS subunit B+ATP
    
• V-ATPase subunit C
  • 1u7l, 3u2f, 3u2y, 3u32, 3ud0 - yATPS subunit C
    
  • 3v3c - ATPS subunit C - pea
    
  • 1ijp, 1l6t – EcF1-ATPS subunit C (mutant) – Escherichia coli - NMR
    
  • 1r5z, 1v9m - TtATPS subunit C – Thermus thermophilus
    
  • 3lg8 - MtATPS subunit C C-terminal
    
  • 2w5j - sATPS subunit C - spinach
    
  • 2wie, 2xqs, 2xqt, 2xqu - ATPS subunit C – Arthrospira platensis
    
  • 3zk1, 3zk2 - ATPS subunit C – Fusobacterium nucleatum
    
• V-ATPase subunit D+F
  • 4rnd – yATPase subunit D+F
    
• V-ATPase subunit E
  • 2kz9 – yATPase subunit E
    
  • 2dm9, 2dma, 4dt0 - PhATPS subunit E – Pyrococcus horikoshii
    
  • 2kk7 - MjATPS subunit E – Methanocaldococcus jannaschii
    
  • 3v6i – TtATPS subunit E + VAPC
    
• V-ATPase subunit F
  • 2qai - ATPS subunit F – Pyrococcus furiosus
    
  • 2i4r - ATPS subunit F – Archaeoglobus fulgidus
    
  • 2ov6 - MmATPS subunit F - NMR
    
  • 2d00 - TtATPS subunit F
    
  • 4ix9 – yATP subunit F (mutant)
    
• V-ATPase subunit G
  • 2k88 - yATPS subunit G - NMR
    
• V-ATPase subunit H
  • 1ho8 – yATPS subunit H
    
• V-ATPase subunit K
  • 2bl2, 2cyd - ATPS subunit K – Enterococcus hirae
    
• V-ATPase subunit I
  • 3rrk – ATPS subunit I N terminal – Meiothermus ruber
  • 4dl0, 4efa - yATPase subunits C,G,E
    
  • 3w3a - yATPS subunit A,B,D,F
    
  • 3a5c, 3a5d - TtATPS subunit A,B,D,F
    
  • 3gqb - TtATPS subunit A (mutant),B (mutant)
    
  • 3k5b - TtATPS subunit E (mutant)+C
    
• P-ATPase
• Cu transporting ATPase
  • 2kmv, 2kmx, 2arf, 2koy – hATPase NBD – human – NMR
    
  • 2kij - hATPase actuator domain – NMR
    
  • 1yjr, 1yjt, 1yju, 1yjv - hATPase (mutant) 6th soluble domain – NMR
    
  • 1y3j, 1y3k - hATPase 5th soluble domain – NMR
    
  • 2ew9 - hATPase 5th+6th soluble domains – NMR
    
  • 1s6o, 1s6u, 2lqb - hATPase 2nd soluble domain – NMR
    
  • 1q8l - hATPase 2nd MBD – NMR
    
  • 1aw0, 2aw0 - hATPase 4th MBD – NMR
    
  • 1kvi, 1kvj - hATPase 1st MBD – NMR
    
  • 3dxs - AtATPase MBD – Arabidopsis thaliana
    
  • 3voy - AfATPase – Archaeoglobus fulgidus – CryoEM
    
  • 3skx, 3sky - AfATPase NBD
    
  • 2k1r - hATPase MBD+ ATOX1 – NMR
    
  • 2rop, 2g9o, 2ga7 - hATPase MBD – NMR
    
  • 2rml - BsATPase N-terminal – Bacillus subtilis – NMR
    
  • 2gcf - sATPase N-terminal - Synechocystis – NMR
    
  • 4a4j - sATPase N-terminal
    
  • 4a48 - sATPase
    
  • 2iye - SsATPase catalytic domain – Sulfolobus solfataricus
    
  • 2yj3 - SsATPase catalytic domain (mutant)
    
  • 2yj4, 2yj5, 2yj6 - SsATPase catalytic domain (mutant) + nucleotide
    
  • 1fvq, 1fvs - hATPase – NMR
    
  • 3cjk – hATPase + Cu transporting protein ATX1
    
  • 3rfu, 4bbj, 4bev, 4byg – ATPase – Legionella pneumophila
    
  • 4f2f - ATPase metal-binding domain – Streptococcus pneumonia
    
  • 3j08, 3j09 - AfATPase
    
  • 3a1c – AfATPase + AMPPCP
    
  • 3a1d - AfATPase + ADP-Mg
    
  • 3a1e - AfATPase (mutant) + AMPPCP
    
• Na/K transporting ATPase
  • 3a3y - SaATPase+K+ouabain – Squalus acanthias
    
  • 3kdp, 3b8e – pATPase – pig
    
  • 3n23 – pATPase + ouabain
    
  • 3wgv, 3wgu – pATPase + oligomycin
    
  • 3b8e - pATPase a+BeF3
    
  • 2hc8 –AfATPase CopA A domain
    
  • 2b8e - AfATPase CopA NBD
    
  • 2xze - SaATPase
    
  • 1mo8, 1mo7 - ATPase α-1 – rat
    
  • 1q3i - pATPase NBD
    
  • 3n2f, 4ret, 4res, 4hyt, 4hqj - pATPase subunits α,β,γ
    
  • 2zxe - ATPase subunits α,β + phospholemman-like protein – spiny dogfish
• Ca+2 transporting ATPase
  • 3fgo - rATPase+CPA+AMPPCP – rabbit
    
  • 3b9r, 1xp5 - rATPase+AlF4
    
  • 1wpg - rATPase+MgF4
    
  • 3w5b - rATPase+Mg
    
  • 4h1w, 3w5a - rATPase+ sarcolipin
    
  • 3w5c, 3w5d, 1iwo - rATPase
    
  • 4bew - rATPase+ phosphate analog
    
  • 2zbe, 3b9b – rATPase+BeF3
    
  • 2zbf - rATPase+BeF3+TG
    
  • 2zbg - rATPase+AlF4+TG
    
  • 2zbd, 3ar8 - rATPase+AlF4+nucleotide+Ca
    
  • 3ar9 - rATPase+BeF3+nucleotide
    
  • 2dqs, 3ar2, 1vfp - rATPase+AMPPCP
    
  • 2c88, 2c8k, 3ar4, 3ar3, 3ar5, 3ar7 - rATPase+nucleotide+TG
    
  • 2ear, 2c8l - rATPase+TG
    
  • 2agv - rATPase+TG+BHQ
    
  • 2eas - rATPase+CPA
    
  • 2eat - rATPase+CPA+GT
    
  • 3ar6 - rATPase+TNP-ADP+GT
    
  • 2eau - rATPase+CPA+curcumin
    
  • 3ba6 - rATPase phosphoenzyme intermediate
    
  • 3fpb - rATPase+ATP+cyclopiazonic acid
    
  • 3fps, 2oa0 - rATPase+ADP+cyclopiazonic acid
    
  • 2o9j - rATPase+MgF4+cyclopiazonic acid
    
  • 1kju, 3n5k - rATPase E2 state
    
  • 2c9m - rATPase Ca2E1 state
    
  • 1t5s, 3n8g - rATPase Ca2E1 state+AMPPCP
    
  • 4nab - rATPase Ca2E1 state (mutant) +AMPPCP
    
  • 1t5t - rATPase Ca2E1 state+ADP+AlF4
    
  • 1su4 - rATPase +2Ca2
    
  • 2by4, 2yfy, 3nal, 3nam, 3nan, 4uu1, 4uu0, 4j2t - rATPase HNE2 state+thapsigargin derivative
• Zn+2 transporting ATPase
  • 2ofg, 2ofh - sATPase N-terminal – NMR
    
  • 4umw, 4umv - ATPase +Mg – Shigella sonni
    
• K+ transporting ATPase
  • 2a00, 2a29 - EcATPase NBD of KdpB+AMPPNP– Escherichia coli – NMR
    
  • 1svj, 1u7q - EcATPase NBD of KdpB – NMR
    
  • 2ynr, 4ux2, 4ux1 – pATPase – Cryo EM
• As+ transporting ATPase
  • 1ii0, 1f48 - EcATPase
    
  • 1ihu – EcATPase+Mg+ADP+AlF3
    
  • 1ii9 - EcATPase
    
  • 3h84, 3idq, 3a36, 3a37 - yATPase GET3
    
  • 4pwx - yATPase GET3 + golgi to ER traffic protein + ubiquitin-like protein
    
  • 3sja, 3sjb, 3sjc, 3sjd, 3zs8, 3zs9, 3b2e, 3vlc - yATPase GET3 + GET1 cystolic domain
    
  • 3ibg - ATPase GET3 – Aspergillus fumigatus
• H+ transporting ATPase
  • 3b8c - AtATPase C terminal truncated
    
  • 1mhs - ATPase – Neurospora crassa
    
• Na+ transporting ATPase
  • 2db4, 3aou - EhATPase subunit K – Enterococcus hirae
    
  • 3aon - EhATPase subunits D,G
    
  • 3vr2 - EhATPase subunits A,B
    
  • 3vr4, 3vr5 - EhATPase subunits A,B,D,G
    
  • 3vr3 - EhATPase subunits A,B + AMPPNP
    
  • 3vr6 - EhATPase subunits A,B,D,G + AMPPNP
    
  • 1yce - ATPase rotor ring – Ilyobacter tartaricus
• H/K transporting ATPase
  • 1iwc, 1iwf - pATPase NBD
    
  • 3ixz - pATPase a+AlF4
    
  • 2xzb – pATPase subunits α, β
    
• Mg+2 transporting ATPase
  • 3gwi – EcATPase P-1 NBD
• Arg/ornithine transporting ATPase
  • 3md0 – MtATPase+GDP – Mycobacterium tuberculosis
    
  • 1kmh - ATPase alpha subunit+tentoxin – spinach
    
  • 1h8e – cATPase+ADP+AlF4+ADP+SO4 - cow
    
  • 1h8h - cATPase+ AMPPNP
    
  • 1efr - cATPase+efrapeptin
    
  • 3fks – yATPase
    
  • 3ea0 – ATPase ParA, fragment – Chlorobium tepidum
    
  • 2qen – ATPase (mutant) Walker-type – Pyrococcus abyssi
    
  • 3cf0, 3cf1, 3cf3 – mATPase NBD+ADP – mouse
    
  • 3cf2 - mATPase NBD+ADP+AMP-PNP
    
  • 2r31, 2p4x – PdATPase ATP12 – Paracoccus denitrificans
    
  • 2zd2 – PdATPase (mutant) ATP12
    
  • 1d8s – EcATPase F1
    
  • 1vdz – PhATPase subunit A – Pyrococcus horikoshii
    
• RNA-dependent ATPase
  • 3eaq, 3i31, 3i32 – TtATPase fragment
    
  • 4kbg, 4kbf - TtATPase helicase core domain
    
  • 4i69, 4i68 - TtATPase RRM domain (mutant)
    
  • 4i67 - TtATPase RRM domain + RNA
    
  • 3mwj – TtATPase N-terminal (mutant)
    
  • 3mwk, 3nbf – TtATPase N-terminal + 8-oxo-AMP
    
  • 3mwl - TtATPase N-terminal (mutant) + 8-oxoadenine
    
  • 3nej - TtATPase reca-like domain (mutant)
• Proteasome-associated ATPase
  • 3fp9, 3m9b, 3m9h – MtATPase intern domain
    
  • 3m91, 3m9d - MtATPase coiled coil domain + protein PUP
    
  • 3kw6 – hATPase 5
• Transitional endoplasmic reticulum ATPase
  • 3hu1, 3hu2, 3hu3 – hTer-ATPase + ATPGS
    
  • 4ko8, 4kln – hTer-ATPase (mutant) + ATPGS
    
  • 4kod – hTer-ATPase (mutant) + ADP
    
  • 3qc8, 3qq8, 3qwz - hTer-ATPase N terminal + FAS-associated factor 1
    
  • 3qq7 - hTer-ATPase N terminal
    
  • 3tiw - hTer-ATPase N terminal + E3 ubiquitin-protein ligase peptide
  • 4kdl, 4kdi - hTer-ATPase N terminal + ubiquitin thioesterase OTU1
    
• LAO/AO transport system ATPase
  • 3nxs – ATPase – Mycobacterium smegmatis
• DNA double-strand repair ATPase (Rad50)
  • 3aux – MjRad50 – Methanocaldococcus jannaschii
    
  • 3auy - MjRad50 + ADP
    
  • 3av0 - MjRad50 + ATP
    
  • 3qg5 – Rad50 NBD + MRE11 – Thermotoga maritima
    
  • 3qkr, 3qks, 3qf7 - PfRad50 NBD + MRE11 – Pyrococcus furiosus
    
  • 4nck, 4nci, 4nch - PfRad50 NBD (mutant)
    
  • 4ncj - PfRad50 NBD (mutant) + BeF3 + ADP
    
  • 3qkt - PfRad50 NBD + AMPPNP
    
  • 3qku - PfRad50 NBD + AMPPNP + MRE11
• MipZ ATPase
  • 2xit, 2xj4 – CcMipZ – Caulobacter crescentus
    
  • 2xj9 – CcMipZ (mutant)
  • 3nbx – EcATPase Rava + ADP
• FlaI ATPase
  • 4ihq, 4ii7 – ATPase (mutant) – Sulfolobus acidocaldarius
    

• The RuvBL1/RuvBL2 complex (ATPase)'
  
  • Journal:JSB:1 - Structural and functional insights into a dodecameric molecular machine

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Mark Hoelzer, Marius Mihasan, Jaime Prilusky, Karsten Theis, Michal Harel, Wayne Decatur