5hzb: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5hzb is ~~ON HOLD~~

==Crystal structure of GII.10 P domain in complex with 2-fucosyllactose (2'FL)==

== Structural highlights ==

<table><tr><td colspan='2'>[[5hzb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HZB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HZB FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hzb OCA], [http://pdbe.org/5hzb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hzb RCSB], [http://www.ebi.ac.uk/pdbsum/5hzb PDBsum]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

Histo-blood group antigens (HBGAs) are important binding factors for norovirus infections. We show that two human milk oligosaccharides, 2' -fucosyllactose (2' FL) and 3-fucosyllactose (3FL), could block norovirus from binding to surrogate HBGA samples. We found that 2' FL and 3FL bound at the equivalent HBGA pocket on the norovirus capsid using X-ray crystallography. Our data revealed that 2' FL and 3FL structurally mimic HBGAs. These results suggest that 2' FL and 3FL might act as natural-occurring decoys in humans.

~~Authors: Hansman~~, G.S., Koromyslova, A~~.D.~~, Singh, B.K.S.

Structural Basis for Norovirus Inhibition by Human Milk Oligosaccharides.,Weichert S, Koromyslova A, Singh BK, Hansman S, Jennewein S, Schroten H, Hansman GS J Virol. 2016 Feb 17. pii: JVI.03223-15. PMID:26889023<ref>PMID:26889023</ref>

~~Description: Crystal structure~~ of ~~GII~~.~~10 P domain in complex with 2~~-~~fucosyllactose (2'FL)~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

[[Category: ~~Unreleased Structures~~]]

</div>

[[Category: Singh, B.K.S]]

[[Category: ~~Koromyslova, A.D~~]]

== References ==

[[Category: ~~Hansman, G.S~~]]

__TOC__

</StructureSection>

[[Category: Hansman, G S]]

[[Category: Koromyslova, A D]]

[[Category: Singh, B K.S]]

[[Category: 2-fucosyllactose]]

[[Category: Hmo]]

[[Category: Human milk]]

[[Category: Norovirus capsid]]

[[Category: P domain]]

[[Category: Viral protein]]

[[Category: Virus]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5hzb is ON HOLD
+==Crystal structure of GII.10 P domain in complex with 2-fucosyllactose (2'FL)==
+<StructureSection load='5hzb' size='340' side='right' caption='[[5hzb]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5hzb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HZB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HZB FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hzb OCA], [http://pdbe.org/5hzb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hzb RCSB], [http://www.ebi.ac.uk/pdbsum/5hzb PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Histo-blood group antigens (HBGAs) are important binding factors for norovirus infections. We show that two human milk oligosaccharides, 2' -fucosyllactose (2' FL) and 3-fucosyllactose (3FL), could block norovirus from binding to surrogate HBGA samples. We found that 2' FL and 3FL bound at the equivalent HBGA pocket on the norovirus capsid using X-ray crystallography. Our data revealed that 2' FL and 3FL structurally mimic HBGAs. These results suggest that 2' FL and 3FL might act as natural-occurring decoys in humans.
-Authors: Hansman, G.S., Koromyslova, A.D., Singh, B.K.S.
+Structural Basis for Norovirus Inhibition by Human Milk Oligosaccharides.,Weichert S, Koromyslova A, Singh BK, Hansman S, Jennewein S, Schroten H, Hansman GS J Virol. 2016 Feb 17. pii: JVI.03223-15. PMID:26889023<ref>PMID:26889023</ref>
-Description: Crystal structure of GII.10 P domain in complex with 2-fucosyllactose (2'FL)
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Singh, B.K.S]]
+<div class="pdbe-citations 5hzb" style="background-color:#fffaf0;"></div>
-[[Category: Koromyslova, A.D]]
+== References ==
-[[Category: Hansman, G.S]]
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Hansman, G S]]
+[[Category: Koromyslova, A D]]
+[[Category: Singh, B K.S]]
+[[Category: 2-fucosyllactose]]
+[[Category: Hmo]]
+[[Category: Human milk]]
+[[Category: Norovirus capsid]]
+[[Category: P domain]]
+[[Category: Viral protein]]
+[[Category: Virus]]