Gelsolin: Difference between revisions

Revision as of 09:34, 6 March 2016

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Human gelsolin G4-G6 (gold) complex with actin (grey), ATP (stick model) and Ca+2 ion (green) (PDB entry 1h1v)

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Updated on 06-March-2016

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 <StructureSection load='1h1v' size='350' side='right' caption='Human gelsolin G4-G6 (gold) complex with actin (grey), ATP (stick model) and Ca+2 ion (green)  (PDB entry [[1h1v]])' scene=''>
 == Function ==
-[[Gelsolin]] (GLS) is a protein regulator of actin assembly and disassembly<ref>PMID:10559185</ref>.
+[[Gelsolin]] (GLS) is a protein regulator of actin assembly and disassembly<ref>PMID:10559185</ref>.  Binding of Ca+2 ion to GLS induces conformational change which enables it to bind actin.
 == Structural highlights ==
-The image at the top left corresponds to the human gelsolin ([[3ffn]]), it has <scene name='Gelsolin/Cv/2'>dimeric form</scene>. It contains 6 homologous domains S1 to S6.
+GLS contains 6 homologous domains G1 to G6.  The human GLS domains span residues: 15-135, 136-248, 249-367, 394-513, 514-619 and 620-734.  The binding site of Ca+2 ion includes Glu, Asp and 2 carbonyl oxygens<ref>PMID:12460571</ref>.
+</StructureSection>
 == 3D Structures of GLS ==
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 **[[2x1o]], [[2x1p]], [[2x1q]] – GLS nanobody - Llama
-* GLS domains S1-S3
+* GLS domains G1-G3
 **[[3ffk]] – hGLS +actin <br />
 **[[1rgi]] - hoGLS +actin <br />
-* GLS domains S4-S6
+* GLS domains G4-G6
-**[[1h1v]] - hGLS +actin<br />
+**[[1h1v]] - hGLS +actin + Ca + ATP<br />
 **[[1nph]] - mGLS +Ca – mouse<br />
-* GLS domain S1
+* GLS domain G1
 **[[2ff3]] - hGLS +N-WASP+actin<br />