Neurexin: Difference between revisions
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{{STRUCTURE_3bod| PDB=3bod | SIZE=400| SCENE= |right|CAPTION=Mouse neurexin 1α LNS domain with Ca+2 ion ([[3bod]]) }} | {{STRUCTURE_3bod| PDB=3bod | SIZE=400| SCENE= |right|CAPTION=Mouse neurexin 1α LNS domain with Ca+2 ion ([[3bod]]) }} | ||
== Function == | |||
[[Neurexin|Neurexins]] (NRXN) are a family of presynaptic proteins which bind to the postsynaptic [[Neuroligin]] (NLGN) to form a complex which attaches neurons. The NRXN family contains 4 members which are numbered 1 to 4<ref>PMID:12796785</ref>. The NRXN-α contains 6 homologous LNS domains while the NRXN-β contains only LNS6. | [[Neurexin|Neurexins]] (NRXN) are a family of presynaptic proteins which bind to the postsynaptic [[Neuroligin]] (NLGN) to form a complex which attaches neurons. The NRXN family contains 4 members which are numbered 1 to 4<ref>PMID:12796785</ref>. The NRXN-α contains 6 homologous LNS domains while the NRXN-β contains only LNS6. | ||
See: [[Neurodevelopmental Disorders]]<br /> | See: [[Neurodevelopmental Disorders]]<br /> | ||
[[Neuroligin-Neurexin Interaction]] | [[Neuroligin-Neurexin Interaction]] | ||
== Relevance == | |||
NRXN sequence variants may contribute to autism spectrum disorder and other cognitive diseases<ref>PMID:18179900</ref>. | |||
== 3D Structures of Neurexin == | == 3D Structures of Neurexin == | ||
