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| == Disease == | | == Disease == |
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| Mutations in Pre are associated with non-syndromic hearing loss. | | Mutations in Pre are associated with non-syndromic hearing loss<ref>PMID:12719379</ref>. |
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| == Structural highlights == | | == Structural highlights == |
Revision as of 10:16, 11 July 2016
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Function
Prestin (Pre) is a motor protein found in the outer hair cells of the cochlea. It is essential for mammalian hearing. Pre is a membranal anion transporter[1]. See STAS domain of the SLC26 anion transporter prestin.
Disease
Mutations in Pre are associated with non-syndromic hearing loss[2].
Structural highlights
Pre C-terminal is mainly composed of a STAS (Sulfate Transporters and Anti-Sigma factor antagonist) domain[3].
- ↑ Zheng J, Shen W, He DZ, Long KB, Madison LD, Dallos P. Prestin is the motor protein of cochlear outer hair cells. Nature. 2000 May 11;405(6783):149-55. PMID:10821263 doi:https://dx.doi.org/10.1038/35012009
- ↑ Liu XZ, Ouyang XM, Xia XJ, Zheng J, Pandya A, Li F, Du LL, Welch KO, Petit C, Smith RJ, Webb BT, Yan D, Arnos KS, Corey D, Dallos P, Nance WE, Chen ZY. Prestin, a cochlear motor protein, is defective in non-syndromic hearing loss. Hum Mol Genet. 2003 May 15;12(10):1155-62. PMID:12719379
- ↑ Pasqualetto E, Aiello R, Gesiot L, Bonetto G, Bellanda M, Battistutta R. Structure of the cytosolic portion of the motor protein prestin and functional role of the STAS domain in SLC26/SulP anion transporters. J Mol Biol. 2010 Jul 16;400(3):448-62. Epub 2010 May 21. PMID:20471983 doi:10.1016/j.jmb.2010.05.013
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3D Structures of prestin
Updated on 11-July-2016
STAS domain of the SLC26 anion transporter prestin – rPre STAS domain – rat
5eus – rPre STAS domain + Br
5euu – rPre STAS domain + Cl
5euz – rPre STAS domain + I
5euw – rPre STAS domain + NO3
5eux – rPre STAS domain + CNS
5ezb – Pre STAS domain - chicken
References
