Pyrin domain: Difference between revisions
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{{STRUCTURE_2km6| PDB=2km6 | SIZE=300| SCENE=Pyrin_domain/Pyrin_domain/1 |right|CAPTION=NMR structure of pyrin domain in human NLRP7, [[2km6]] }} | {{STRUCTURE_2km6| PDB=2km6 | SIZE=300| SCENE=Pyrin_domain/Pyrin_domain/1 |right|CAPTION=NMR structure of pyrin domain in human NLRP7, [[2km6]] }} | ||
== Function == | |||
'''Pyrin domain''' (PYD) is a protein domain known as death fold. This domain allows the protein to interact with other pyrin domains. It is also known as PYD or PAAD/DAPIN or marenostrin domain. Proteins containing pyrin domain are involved in inflammation and apoptosis. The NALP proteins contain domains NACHT, LRR and PYD and are part of the inflammasome. A 781-amino acid protein named pyrin contains a PYD domain in its N-terminal<ref>PMID:11514682</ref>. | |||
== Disease == | |||
Mutations in the protein are the cause of Familial Mediterranean fever<ref>PMID:17431422</ref>. | |||
== 3D Structures of Pyrin domain == | == 3D Structures of Pyrin domain == | ||
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[[2dbg]] – hPYD in myeloid cell nuclear differentiation antigen - NMR<BR /> | [[2dbg]] – hPYD in myeloid cell nuclear differentiation antigen - NMR<BR /> | ||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
