3zoj

High-resolution structure of Pichia Pastoris aquaporin Aqy1 at 0.88 A

spinqualitylabelsall models 3zoj, resolution 0.88Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3zoj is a 1 chain structure with sequence from Atcc 28485. The May 2014 RCSB PDB Molecule of the Month feature on Aquaporin by David Goodsell is 10.2210/rcsb_pdb/mom_2014_5. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: BOG, CL Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Aquaporins are membrane channels that facilitate the flow of water across biological membranes. Two conserved regions are central for selective function: the dual asparagine-proline-alanine (NPA) aquaporin signature motif and the aromatic and arginine selectivity filter (SF). Here, we present the crystal structure of a yeast aquaporin at 0.88 angstrom resolution. We visualize the H-bond donor interactions of the NPA motif's asparagine residues to passing water molecules; observe a polarized water-water H-bond configuration within the channel; assign the tautomeric states of the SF histidine and arginine residues; and observe four SF water positions too closely spaced to be simultaneously occupied. Strongly correlated movements break the connectivity of SF waters to other water molecules within the channel and prevent proton transport via a Grotthuss mechanism. Subangstrom resolution X-ray structure details aquaporin-water interactions.,Kosinska Eriksson U, Fischer G, Friemann R, Enkavi G, Tajkhorshid E, Neutze R Science. 2013 Jun 14;340(6138):1346-9. doi: 10.1126/science.1234306. PMID:23766328 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Aquaporin

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