Semaphorin: Difference between revisions
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== Function == | == Function == | ||
'''Semaphorin''' (SEMA) are membrane proteins which act as axonal growth guidance molecules. SEMA act as short-range inhibitory signal<ref>PMID:10934324</ref>. There are 8 classes of SEMA numbered 1 to 7 and V (viral). Each class has several subgroups which share similar characteristics. | '''Semaphorin''' (SEMA) are membrane proteins which act as axonal growth guidance molecules. SEMA act as short-range inhibitory signal<ref>PMID:10934324</ref>. There are 8 classes of SEMA numbered 1 to 7 and V (viral). Each class has several subgroups which share similar characteristics. | ||
*'''Semaphorin 3''' is needed for normal patterning and growth of nerves, bones and heart<ref>PMID:8849723</ref>.<br /> | |||
*'''Semaphorin 4D''' acts through its receptor to tip the balance of bone homeostasis toward resorption <ref>PMID:26910109</ref>.<br /> | |||
*'''Semaphorin 7A''' promotes axon growth through integrins and MAPKs <ref>PMID:12879062</ref>.<br /> | |||
== Relevance == | == Relevance == | ||
