Sphingomyelinase: Difference between revisions
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{{STRUCTURE_1zwx| PDB=1zwx | SIZE=400| SCENE= |right|CAPTION=Sphingomyelinase complex with glycerol and phosphate ion [[1zwx]] }} | {{STRUCTURE_1zwx| PDB=1zwx | SIZE=400| SCENE= |right|CAPTION=Sphingomyelinase complex with glycerol and phosphate ion [[1zwx]] }} | ||
== Function == | |||
'''Sphingomyelinase''' (SMase) is a hydrolase involved in sphingolipid metabolism. It catalyzes the breakdown of sphingomyelin (SM) to phosphocholine and ceramide<ref>PMID:11001563</ref>. The SMase is classified into 5 types according to their pH dependence and cation dependence. | |||
== Disease == | |||
Mutations in acid SMase are found in patients with Niemann-Pick disease<ref>PMID:17011332</ref>. | |||
==3D structures of sphingomyelinase== | ==3D structures of sphingomyelinase== | ||
