Sphingomyelinase: Difference between revisions
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==3D structures of sphingomyelinase== | ==3D structures of sphingomyelinase== | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
{{#tree:id=OrganizedByTopic|openlevels=0| | |||
*SMase | |||
[[3rlh]], [[3rlg]] – SMase D (mutant) – ''Loxosceles intermedia''<br /> | **[[3rlh]], [[3rlg]] – SMase D (mutant) – ''Loxosceles intermedia''<br /> | ||
[[1xx1]], [[2f9r]] – SMase I – ''Loxosceles laeta''<br /> | **[[1xx1]], [[2f9r]] – SMase I – ''Loxosceles laeta''<br /> | ||
[[1zwx]] – SMase C – ''Listeria ivanovii''<br /> | **[[1zwx]] – SMase C – ''Listeria ivanovii''<br /> | ||
[[2ddr]], [[2dds]], [[2ddt]] – BcSMase + cation – ''Bacillus cereus''<br /> | **[[2ddr]], [[2dds]], [[2ddt]] – BcSMase + cation – ''Bacillus cereus''<br /> | ||
[[2uyr]] – BcSMase (mutant)<br /> | **[[2uyr]] – BcSMase (mutant)<br /> | ||
[[3wcx]] – SMase C – ''Streptomyces griseocarneus''<br /> | **[[3wcx]] – SMase C – ''Streptomyces griseocarneus''<br /> | ||
*Acid SMase | |||
**[[5fib]] – mSMase – mouse<br /> | |||
**[[5hqn]] – mSMase catalytic domain<br /> | |||
**[[5fi9]] – mSMase + inhibitor<br /> | |||
**[[5fic]] – mSMase + lipid<br /> | |||
}} | |||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:11, 31 August 2016
Function
Sphingomyelinase (SMase) is a hydrolase involved in sphingolipid metabolism. It catalyzes the breakdown of sphingomyelin (SM) to phosphocholine and ceramide[1]. The SMase is classified into 5 types according to their pH dependence and cation dependence.
Disease
Mutations in acid SMase are found in patients with Niemann-Pick disease[2].
3D structures of sphingomyelinase
Updated on 31-August-2016
- ↑ Chatterjee S. Neutral sphingomyelinase: past, present and future. Chem Phys Lipids. 1999 Nov;102(1-2):79-96. PMID:11001563
- ↑ Wasserstein MP, Aron A, Brodie SE, Simonaro C, Desnick RJ, McGovern MM. Acid sphingomyelinase deficiency: prevalence and characterization of an intermediate phenotype of Niemann-Pick disease. J Pediatr. 2006 Oct;149(4):554-9. PMID:17011332 doi:https://dx.doi.org/10.1016/j.jpeds.2006.06.034
