Subtilisin: Difference between revisions
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{{STRUCTURE_2z2x| PDB=2z2x | SIZE=400| SCENE=Subtilisin/Cv/1 |right|CAPTION=Subtilisin with monoisopropylphosphorylserine complex with Ca+2 ions (green) [[2z2x]] }} | {{STRUCTURE_2z2x| PDB=2z2x | SIZE=400| SCENE=Subtilisin/Cv/1 |right|CAPTION=Subtilisin with monoisopropylphosphorylserine complex with Ca+2 ions (green) [[2z2x]] }} | ||
== Function == | |||
[[Subtilisin]] is a serine protease. A 77 amino acid propeptide is cleaved from the N-terminus of pro-Sub to create the mature active enzym<ref>PMID:4967581</ref>. See detalis in [[User:Tommie Hata/Introduction to Protein Engineering-Subtilisin]]. | |||
*'''Selenosubtilisin''' is a semisynthetic selenoenzyme produced by chemical modification of subtilisin<ref>PMID:8385489</ref>.<br /> | |||
*'''Savinase''' is a subtilisin produced from a lentil<ref>PMID:24738747</ref>.<br /> | |||
== Relevance == | |||
Subtilisin is widely used commercially in detergents. | |||
== 3D Structures of Subtilisin == | == 3D Structures of Subtilisin == | ||
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**[[2wwt]], [[2x8j]] - pro-BcSub (mutant)<br /> | **[[2wwt]], [[2x8j]] - pro-BcSub (mutant)<br /> | ||
**[[3whi]] - pro-BcSub (mutant)<br /> | **[[3whi]] - pro-BcSub (mutant)<br /> | ||
* Mature subtilisin complexed with its propeptide | * Mature subtilisin complexed with its propeptide | ||
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**[[3bx1]], [[1svn]], [[4cfy]], [[4cfz]], [[4cg0]] – Sav – ''Bacillus lentus'' | **[[3bx1]], [[1svn]], [[4cfy]], [[4cfz]], [[4cg0]] – Sav – ''Bacillus lentus'' | ||
}} | }} | ||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
