Villin

spinqualitylabelsall models Human supervillin headpiece, 2k6n Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Villin (VIL) is an actin-binding protein. It contains gelsolin-like domains in its N-terminal and a helical headpiece which binds actin. Supervillin (SVIL) contains numerous gelsolin-like domains in its C-terminal and interacts with actin. Advillin (AVIL) is another actin-binding protein in the gelsolin superfamily which is expressed in the peripheral sensory neurons. Cytovillin (CVIL) or ezrin or villin-2 serves as intermediate between plasma membrane and actin cytoskeleton. Relevance VIL immunohisochemistry is a reliable method for diagnosing microvillus inclusion disease (MVID).

3D Structures of Villin

Updated on 13-December-2016

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• Supervillin
  • gelsolin, 2k6n – hSVIL headpiece– human – NMR
    
• Villin
  • 3fg7 – hVIL gelsolin domains 4-6
    
  • 2llf - hVIL gelsolin-like domain 6 - NMR
    
  • 1unc – hVIL headpiece
    
  • 3iur - hVIL headpiece H2H3 helices+prolyl endopeptidase – Aeromonas punctata
    
  • 2rjw, 2rjx, 2rjv, 2rjy, 1yu7, 1yu8 – cVIL headpiece (mutant) – chicken
    
  • 1yu5, 1qqv - cVIL headpiece
    
  • 3myc, 3mye, 3nkj, 3mya, 3tjw, 3trv, 3trw, 3try - cVIL headpiece (mutant)
    
  • 1vii, 2vik, 2vil, 4cz3, 4cz4 - cVIL headpiece - NMR
    
  • 2ppz, 2jm0 - VIL headpiece (mutant) – synthetic – NMR
    
  • 2f4k, 1wy3, 1wy4, 1yrf, 1yri - VIL fragment (mutant) – synthetic
    
• Advillin
  • 1und – hAVIL headpiece
    
• Cytovillin
  • 1ni2 – hCVIL N terminal
    

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Alexander Berchansky, Michal Harel, Jaime Prilusky, David Canner, Joel L. Sussman