4xuu: Difference between revisions
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==The hSac2 domain from human phosphoinositide phosphatase Sac2== | ==The hSac2 domain from human phosphoinositide phosphatase Sac2== | ||
<StructureSection load='4xuu' size='340' side='right' caption='[[4xuu]], [[Resolution|resolution]] 2.62Å' scene=''> | <StructureSection load='4xuu' size='340' side='right' caption='[[4xuu]], [[Resolution|resolution]] 2.62Å' scene=''> | ||
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<table><tr><td colspan='2'>[[4xuu]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XUU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XUU FirstGlance]. <br> | <table><tr><td colspan='2'>[[4xuu]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XUU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XUU FirstGlance]. <br> | ||
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xuu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xuu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xuu RCSB], [http://www.ebi.ac.uk/pdbsum/4xuu PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xuu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xuu OCA], [http://pdbe.org/4xuu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xuu RCSB], [http://www.ebi.ac.uk/pdbsum/4xuu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xuu ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/SAC2_HUMAN SAC2_HUMAN]] Inositol 5-phosphatase which acts on phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Hydrolyzes phosphatidylinositol 4,5-bisphosphate most effectively. Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation.<ref>PMID:11274189</ref> <ref>PMID:17322895</ref> | [[http://www.uniprot.org/uniprot/SAC2_HUMAN SAC2_HUMAN]] Inositol 5-phosphatase which acts on phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Hydrolyzes phosphatidylinositol 4,5-bisphosphate most effectively. Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation.<ref>PMID:11274189</ref> <ref>PMID:17322895</ref> | ||
==See Also== | |||
*[[Phosphoinositide phosphatase|Phosphoinositide phosphatase]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 01:51, 10 March 2017
The hSac2 domain from human phosphoinositide phosphatase Sac2
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