Dehalogenase

spinqualitylabelsall models Structure of haloalkane dehalogenase complex with I- ion (purple) (PDB code 2edc). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Dehalogenases catalyze the removal of halogen atom from substrates. • Haloalkane dehalogenase converts haloalkanes to alcohol • Halohydrin dehalogenase converts halohydrins to epoxide • L-2 haloacid dehalogenase converts L-2-haloacids to D-2-hydroxyacid • S-2 haloacid dehalogenase converts S-2-haloacids to R-2-hydroxyacid • 4-chlorobenzoyl CoA dehalogenase converts 4-chlorobenzoyl CoA to 4-hydroxybenzoyl CoA • Fluoroacetate dehalogenase converts fluoroacetate to glycolate • Iodotyrosine dehalogenase converts iodotyrosine to tyrosine • cis- and trans-3-chloroacrylic acid dehalogenase converts 3-chloroacrylate to malonate semialdehyde • 5-chloromuconolactone dehalogenase converts 5-chloromuconolactone to E-dienelactone. • Tetrachloroethene reductive dehalogenase catalyzes the conversion of trichloroethene, Cl- and acceptor to tetrachloroethene and reduced acceptor. Relevance Haloalkane dehalogenase is tested for the biodegredation of toxic industrial by-products. Fluoroacetate dehalogenase is tested for the biodegredation of the poisonous fluroacetate which can kill livestock and is found in some plants in Australia, Africa and Central America. Structural highlights In the fluoroacetate dehalogenase complex with halide, the iodide is seen in the active site cavity between two tryptophans (in cyan).

3D structures of dehalogenase

Updated on 16-January-2018

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• Haloalkane dehalogenase
  • 4c6h – RbHLD + hexanol – Rhodobacteraceae
    
  • 1bn6, 1bn7, 4kaf, 4kaa, 4kac – RrHLD – Rhodococcus rhodochrous
    
  • 5y2x – RrHLD (mutant)
    
  • 4e46 – RrHLD + propanol
    
  • 3u1t – HLD DmmA – marine
    
  • 2had, 1ede, 2pky, 2yxp, 1edb – XaHLD – Xanthobacter autotrophicus
    
  • 1be0, 1bee, 1hde, 1bez – XaHLD (mutant)
    
  • 3wi7 – AtHLD DatA – Agrobacterium tumefaciens
    
  • 3wib – AtHLD DatA (mutant)
    
  • 2xt0 – HLD DppA – Plesiocystis pacifica
    
• Haloalkane dehalogenase from Rhodococcus rhodochrous DhaA
  • 5flk, 2v9z – RrHLD DhaA (mutant)
    
  • 4hzg – RrHLD DhaA + Cl
    
  • 3rk4, 3fbw, 3fwh, 3g9x, 3sk0, 4wcv – RrHLD DhaA (mutant) + Cl
    
  • 4fwb – RrHLD DhaA (mutant) + trichloropropane
    
• Haloalkane dehalogenase from Sphingomonas paucimobolis LinB
  • 1cv2 – SpHLD LinB
    
  • 5lka – SpHLD LinB (mutant)
    
  • 1k5p, 1mj5, 4h77, 1iz7, 2bfn, 1g4h – SpHLD LinB + Cl
    
  • 4h7d, 4h7e, 4h7f, 4h7h, 4h7i, 4h7j, 4h7k, 4wdq, 4wdr – SpHLD LinB (mutant) + Cl
    
  • 1k6e – SpHLD LinB + Cl + Br
    
  • 1k63 – SpHLD LinB + Br-propanol
    
  • [1d07]], 1iz8 – SpHLD LinB + Br
    
  • 1g42 – SpHLD LinB + trichloropropane
    
  • 1g5f – SpHLD LinB + trichloroethane
    
• Haloalkane dehalogenase complex with halogen
  • 2dhc – XaHLD + dichloroethane
    
  • 2dhd – XaHLD + chloroethoxy oxobutanoic acid
    
  • 2dhe, 1edd – XaHLD + Cl
    
  • 2eda, 2edc – XaHLD + I
    
  • 4mj3 – HLD DmrA + Cl – Mycobacterium rhodesiae
    
  • 2qvb – MtHLD 3 + Cl – Mycobacterium tuberculosis
    
  • 2o2h – MtHLD 3 + dichloroethane
    
  • [2o2i]] – MtHLD 3 + Br
    
  • 1b6g – XaHLD + Cl
    
  • 1cij – XaHLD + Br
    
  • 1cqw – RrHLD + I
    
  • 5uxz, 5y2y, 5vnp – RrHLD + Cl + fluorogenic ligand
    
  • 5uy1 – RrHLD + Cl
    
  • 4f5z – RrHLD (mutant) + Cl
    
  • 4f60 – RrHLD (mutant) + F
    
  • 4brz – RbHLD + Cl
    
  • 4k2a – HLD DbeA + Cl – Bradyrhizobium elkanii
    
  • 3a2m, 3a2n, 3afi – BjHLD DbjA + Cl – Bradyrhizobium japonicum
    
  • 3a2l – BjHLD DbjA (mutant) + Cl
    
  • 5esr – HLD DccA + Cl – Caulobacter crescentus
    
• Fluoroacetate dehalogenase (FDH)
  • 1y37 – BuFDH – Burkholderia
    
  • 3r3u – RpFDH – Rhodopseudomonas palustris
    
  • 3r40, 3r41, 5t4t – RpFDH (mutant)
    
• Fluoroacetate dehalogenase complexes
  • 3r3v, 3r3y, 5swn – RpFDH (mutant) + fluoroacetate
    
  • 3r3w – RpFDH (mutant) + chloroacetate
    
  • 3r3x – RpFDH (mutant) + bromoacetate
    
  • 3r3z – RpFDH + glycolate
    
  • 3b12 – BuFDH (mutant) + fluoroacetate
    
• Halohydrin dehalogenase (HHDH)
  • 1zmo – HHDH – Anthrobacter
    
  • 3zn2 – AtHHDH
    
• Halohydrin dehalogenase complexes
  • 1pwx – AtHHDH + Br
    
  • 1px0 – AtHHDH + haloalcohol mimic
    
  • 1zo8 – AtHHDH + p-nitrostyrene oxide
    
  • 1pwz, 1zmt – AtHHDH + styrene oxide + Cl
    
  • 4ixt – AtHHDH (mutant) + ethyl cyano-hydroxybutyrate
    
  • 4ixw – RrHHDH (mutant) + ethyl oxiranyl acetate – Rhizobium radiobacter
    
  • 4iy1 – RrHHDH + Cl
    
  • 5kwe – RrHHDH (mutant) + Cl
    
  • 5kvc – RrHHDH (mutant) + imidazole + Cl
    
• L-2-haloacid dehalogenase (LHDH)
  • 1jud – PsLHDH – Pseudomonas
    
  • 2w43 – StLHDH – Sulfolobus tokodaii
    
  • 2yml, 2ymm, 2ymp, 2ymq – RhLHDH
    
  • 4ce6, 4cf3, 4cf4, 4cf5, 4cnq – RhLHDH (mutant)
    
  • 3bjx – LHDH – Pseudomonas putida
    
  • 3umc – LHDH – Pseudomonas aeruginosa
    
  • 3um9 – LHDH – Polaromonas
    
  • 3umg – LHDH – Rhodococcus jostii
    
• L-2-haloacid dehalogenase complexes
  • 1aq6, 1qq5 – XaLHDH + formic acid
    
  • 1zrm – PsLHDH (mutant) + butanoic acid
    
  • 1zrn – PsLHDH (mutant) + acetic acid
    
  • 1qh9 – PsLHDH + lactic acid
    
  • 2w11 – StLHDH + lactic acid
    
  • 1qq6, 1qq7 – XaLHDH + aspartate carboxymethyl ester + Cl
    
  • 2yn4 – RhLHDH + chlorobutyrate
    
• DL-2-haloacid dehalogenase (DLHDH)
  • 4n2x – MeDLHDH – Methylobacterium
    
  • 3wj8 – MeDLHDH + bromo-methylpropionate
    
• S-2-haloacid dehalogenase (SHDH)
  • 2no4 – BcSHDH IVA – Burkholderia cepacia
    
  • 2no5 – BcSHDH IVA + 2-monochloroprapanate
    
• Iodotyrosine dehalogenase (ITDH)
  • 3gb5 – mITDH – mouse
    
  • 3to0 – mITDH (mutant)
    
  • 3gfd – mITDH + iodotyrosine
    
  • 3tnz – mITDH (mutant) + iodotyrosine
    
  • 3gh8 – mITDH + diiodotyrosine
    
  • 4ttb – hITDH 1 + FMN
    
  • 4ttc – hITDH 1 + FMN + iodotyrosine
    
• cis-3-chloroacrylic acid dehalogenase (CaaD)
  • 2flz, 3mf8 – CbCaaD – Coryneform bacterium
    
  • 3mf7 – CbCaaD + oxirane-carboxylate
    
  • 2flt – CbCaaD + lactic acid
    
• trans-3-chloroacrylic acid dehalogenase (TaaD)
  • 3ej3 – PpTaaD α+β subunits – Pseudomonas pavonacea
    
  • 3ej7, 3ej9 – PpTaaD α (mutant) +β subunits
    
  • 1s0y – PpTaaD α+β subunits + malonic acid
    
• 5-chloromuconolactone dehalogenase (ClcF)
  • 3znu, 3znj, 4fpi – RoClcF – Rhodococcus opacus
    
  • 3zo7 – RoClcF + 5-chloromuconolactone
    
• 4-chlorobenzoyl CoA dehalogenase (CBCD)
  • 1nzy – PsCBCD
    
  • 1jxz – PsCBCD + hydroxybenzoyl CoA
    
• Tetrachloroethene reductive dehalogenase (TCRD)
  • 4uqu, 4ur3 – SmTCRD catalytic subunit – Sulfurospirillum multivorans
    
  • 4ur0 – SmTCRD catalytic subunit + trichloroethene
    
  • 4ur1 – SmTCRD catalytic subunit + tribromoethene
    
  • 4ur2 – SmTCRD catalytic subunit + iodide
    

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