Arginase

spinqualitylabelsall models Structure of rat arginase containing Mn+2 (purple) complex with ornithine (cyan) and urea (yellow) (PDB code 1hqg). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Arginase (Arg) catalyzes the conversion of arginine to ornithine and urea. Arg is the final enzyme in the urea cycle. Arg requires 2 manganese ions for functioning. Disease Arg deficiency is an inherited disorder causing the accumulation of toxic urea in the blood. Structural highlights The manganese ions are located at the bottom of a 15A cleft. The proposed reaction mechanism involves H141, D128, E277 in rat. Active site.

3D structures of arginase

Updated on 11-March-2018

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• Arginase
  • 3tf3 – hArg 1 - human
    
  • 2ef4, 2ef5, 2eiv – Arg – Thermus thermophilus
    
  • 4rhi, 4rhj, 4rhk – TbArg – Trypanosoma brucei
    
• Mn containing arginase
  • 1rla, 2rla – rArg + Mn – rat
    
  • 3rla, 4rla, 5rla, 1hqx, 1p8m, 1p8n, 1p8o, 1p8p, 1p8q, 1p8r, 1p8s, 1ta1, 1tbh, 1tbj, 1tbl, 3e8q, 3e8z – rArg (mutant) + Mn
    
  • 1wva, 2pha, 2zav – hArg 1 + Mn
    
  • 1wvb – hArg 1 (mutant) + Mn
    
  • 1cev, 2cev – BcArg + Mn – Bacillus caldovelox
    
  • 4g3h – Arg + Mn – Helicobacter pylori
    
  • 4ity – LmArg + Mn – Leishmania mexicana
    
  • 4q3p – SmArg + Mn – Schistosoma mansoni
    
  • 4rhl, 4rhm, 4rhq – TbArg (mutant) + Mn
    
• Mn containing arginase complexes
  • 1d3v, 1hq5 – rArg + Mn + Arg analog
    
  • 1hqf, 1hqh – rArg + Mn + hydroxyl-Arg
    
  • 1hqg – rArg (mutant) + Mn + ornithine + urea
    
  • 1r1o, 1t4p, 1t4r, 1t4t, 1t5f – rArg + Mn + inhibior
    
  • 1t4s – rArg + Mn + valine
    
  • 1t5g – rArg + Mn + Arg
    
  • 1zpe, 1zpg – rArg (mutant) + Mn + alkylamine derivative
    
  • 3e9b – rArg (mutant) + Mn + Br-ethyl cysteine
    
  • 2aeb, 2pll – hArg 1 + Mn + Arg analog
    
  • 2pho – hArg 1 + Mn + thiosemicarbazide
    
  • 3dj8 – hArg 1 + Mn + amino-epoxy octanoic acid
    
  • 3e6k, 3e6v – hArg 1 (mutant) + Mn + Arg analog
    
  • 3f80 – hArg 1 + Mn + nitro-norleucine
    
  • 3kv2, 3lp7 – hArg 1 + Mn + nor-ω-hydroxy-Arg
    
  • 3gmz – hArg 1 + Mn + ornithine
    
  • 3gn0 – hArg 1 + Mn + ornithine derivative
    
  • 3lp4 – hArg 1 + Mn + lysine
    
  • 3mfv, 3mfw – hArg 1 + Mn + histidine derivative
    
  • 3mjl – hArg 1 + Mn + amino-imidazole
    
  • 3sjt, 3skk, 4hww, 4hxq, 4ie1 – hArg 1 + Mn + inhibitor
    
  • 4fci – hArg 1 + Mn + amino-guanidino propionate
    
  • 3cev – BcArg + Mn + Arg
    
  • 5cev – BcArg + Mn + Lys
    
  • 4iu0, 4iu1, 4iu4, 5hj9, 5hja – LmArg + Mn + inhibitor
    
  • 4iu5 – LmArg + Mn + ornithine
    
  • 4q3q, 4q3r, 4q3s, 4q3t, 4q3u, 4q3v – SmArg + Mn + inhibitor
    
  • 4q40, 4q41 – SmArg + Mn + amino acid
    
  • 4q42 – SmArg + Mn + ornithine
    
  • 4cev – Arg + Mn + ornithine – Bacillus caldovelox
    
  • 3mmr, 3sl0, 3sl1 – Arg + Mn + borohexanoate derivative – Plasmodium falciparium
    
• Co containing arginase
  • 3th7, 3the – hArg 1 + Co
    
  • 3thh – hArg 1 + Co + Arg analog
    
  • 3thj – hArg 1 + Co + ornithine
    
  • 4fck – hArg 1 + Co + amino-guanidino propionate
    
• Ni containing arginase
  • 4gsm – hArg 1 + Ni
    
  • 4gsv – hArg 1 + Ni + Arg analog
    
• Zn containing arginase
  • 4gsz – hArg 1 + Zn + Arg analog
    
• Mn and Zn containing arginase
  • 4gwc – hArg 1 + Mn + Zn
    
  • 4gwd – hArg 1 + Mn + Zn + Arg analog
    
• Arginase 2
  • 1pq3 – hArg 2+ Mn
    
  • 4hze, 4i06, 4ie2, 4ie3, 4ixu, 4ixv – hArg 2 + Mn + inhibitor
    

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