5y06: Difference between revisions
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==Structural characterization of msmeg_4306 from Mycobacterium smegmatis== | |||
<StructureSection load='5y06' size='340' side='right' caption='[[5y06]], [[Resolution|resolution]] 2.61Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5y06]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y06 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Y06 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5y06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y06 OCA], [http://pdbe.org/5y06 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y06 RCSB], [http://www.ebi.ac.uk/pdbsum/5y06 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y06 ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The MSMEG_4306 gene from Mycobacterium smegmatis encodes a protein of unknown function with 242 amino-acid residues that contains a conserved zinc-ribbon domain at its C-terminus. Here, the crystal structure of MSMEG_4306 determined by the single-wavelength anomalous dispersion method using just one zinc ion co-purified with the protein is reported. The crystal structure of MSMEG_4306 shows a coiled-coil helix domain in the N-terminal region and a zinc-ribbon domain in the C-terminal region. A structural similarity search against the Protein Data Bank using MSMEG_4306 as a query revealed two similar structures, namely CT398 from Chlamydia trachomatis and HP0958 from Helicobacter pylori, although they share only approximately 15% sequence identity with MSMEG_4306. Based on comparative analysis, it is predicted that MSMEG_4306 may be involved in secretion systems, possibly by interacting with multiple proteins or nucleic acids. | |||
Crystal structure of the MSMEG_4306 gene product from Mycobacterium smegmatis.,Kumar A, Karthikeyan S Acta Crystallogr F Struct Biol Commun. 2018 Mar 1;74(Pt 3):166-173. doi:, 10.1107/S2053230X18002236. Epub 2018 Feb 26. PMID:29497021<ref>PMID:29497021</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 5y06" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Karthikeyan, S]] | [[Category: Karthikeyan, S]] | ||
[[Category: Kumar, A]] | [[Category: Kumar, A]] | ||
[[Category: Coiled coil helix]] | |||
[[Category: Hypothetical]] | |||
[[Category: Unknown function]] | |||
[[Category: Zinc ribbon]] | |||
[[Category: Zinc-sad]] | |||
Revision as of 08:04, 2 May 2018
Structural characterization of msmeg_4306 from Mycobacterium smegmatis
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