Gelsolin: Difference between revisions
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<StructureSection load='1h1v' size='350' side='right' caption='Human gelsolin | <StructureSection load='1h1v' size='350' side='right' caption='Human gelsolin S4-S6 (gold) complex with actin (cyan), ATP and Ca+2 ion (green) (PDB entry [[1h1v]])' scene='41/410297/Cv/3'> | ||
__TOC__ | __TOC__ | ||
== Function == | == Function == | ||
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== Structural highlights == | == Structural highlights == | ||
GLS contains 6 homologous domains | GLS contains 6 homologous domains S1 to S6. The human GLS domains span residues: 15-135, 136-248, 249-367, 394-513, 514-619 and 620-734. <scene name='41/410297/Cv/4'>S4-S6 are shown</scene>. The <scene name='41/410297/Cv/5'>binding site of Ca+2 ion includes Glu, Asp and 2 carbonyl oxygens</scene><ref>PMID:12460571</ref>. | ||
</StructureSection> | </StructureSection> | ||
== 3D Structures of GLS == | == 3D Structures of GLS == | ||
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{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
* GLS | * GLS residues 1-782 | ||
**[[3ffn]] – hGLS – human <br /> | **[[3ffn]] – hGLS – human <br /> | ||
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**[[2x1o]], [[2x1p]], [[2x1q]] – GLS nanobody - Llama | **[[2x1o]], [[2x1p]], [[2x1q]] – GLS nanobody - Llama | ||
* GLS | * GLS domain S1 residues 51-178 | ||
**[[5h3m]], [[5h3n]] – hGLS – NMR<br /> | |||
**[[2ff3]] - hGLS +N-WASP+actin<br /> | **[[2ff3]] - hGLS +N-WASP+actin<br /> | ||
**[[2ff6]] - hGLS +Ciboulot domain 2+actin<br /> | **[[2ff6]] - hGLS +Ciboulot domain 2+actin<br /> | ||
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**[[1d4x]] - hGLS +CeActin+Mg-ATP – ''Caenorhabditis elegans''<br /> | **[[1d4x]] - hGLS +CeActin+Mg-ATP – ''Caenorhabditis elegans''<br /> | ||
**[[1esv]] - hGLS +rActin+latrunculin – rabbit<br /> | **[[1esv]] - hGLS +rActin+latrunculin – rabbit<br /> | ||
**[[1eqy]] - hGLS +rActin<br /> | **[[1eqy]], [[1p8z]], [[5ubo]] - hGLS +rActin<br /> | ||
**[[1yvn]] - hGLS +yActin (mutant) – yeast<br /> | **[[1yvn]] - hGLS +yActin (mutant) – yeast<br /> | ||
**[[1yag]] - hGLS +yActin<br /> | **[[1yag]] - hGLS +yActin<br /> | ||
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**[[3cjb]] - rGLS +rActin<br /> | **[[3cjb]] - rGLS +rActin<br /> | ||
**[[3cjc]] - rGLS +rActin+DNAse I<br /> | **[[3cjc]] - rGLS +rActin+DNAse I<br /> | ||
**[[4cbu]], [[4cbw]], [[4cbx]] - mGLS +actin+Ca+ATP<br /> | **[[4cbu]], [[4cbw]], [[4cbx]], [[5mvv]] - mGLS +actin+Ca+ATP<br /> | ||
*GLS S2 | *GLS S2 residues 178-293 | ||
**[[5fae]], [[5faf]] - hGLS (mutant) <br /> | **[[5fae]], [[5faf]], [[5o2z]] - hGLS (mutant) <br /> | ||
**[[4s10]] - hGLS (mutant) + antibody<br /> | **[[4s10]] - hGLS (mutant) + antibody<br /> | ||
* GLS | * GLS domains S1-S3 residues 52-426 | ||
**[[3ffk]] – hGLS +actin <br /> | |||
**[[1rgi]] - hoGLS +actin <br /> | |||
* GLS domains S4-S6 residues 439-782 | |||
**[[1h1v]] - hGLS +actin + Ca + ATP<br /> | |||
**[[2fh1]], [[2fh2]], [[2fh3]], [[2fh4]], [[1p8x]] – hGLS + Ca<br /> | |||
**[[1nph]] - mGLS +Ca – mouse<br /> | |||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:58, 29 May 2018
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3D Structures of GLS
Updated on 29-May-2018
