Fibroblast growth factor: Difference between revisions
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* '''FGF1''' is called acidic FGF.<br /> | * '''FGF1''' is called acidic FGF.<br /> | ||
* '''FGF2''' is called basic FGF.<br /> | * '''FGF2''' is called basic FGF.<br /> | ||
* '''FGF7''' is called keratinocyte growth factor which is present in the | * '''FGF4''' has multiple roles during vertebrate embryogenesis<ref>PMID:18792115</ref>.<br /> | ||
* '''FGF7''' is called keratinocyte growth factor which is present in the epitheliazation-phase of wound healing when keratinocytes are covering the wound<ref>PMID:11052999</ref>. FGF7 is aparacrine growth factor in the breast<ref>PMID:12697038</ref>. | |||
* '''FGF8''' has multiple roles in the regulation of embryogenesis, cell differentiation, proliferation and migration. It is required for normal development of normal brain, eye, ear and limb<ref>PMID:22273727</ref>.<br /> | |||
* '''FGF9''' is produced and secreted by the prostatic stromal cells<ref>PMID:10362017</ref>.<br /> | |||
* '''FGF10''' has essential role in the growth of fetal prostate <ref>PMID:12941620</ref>.<br /> | |||
== Relevance == | == Relevance == | ||
FGF signaling is important in the pathogenesis of a variety of tumor types<ref>PMID:20094046</ref>, angiogenesis<ref>PMID:7542215</ref> and wound healing<ref>PMID:12696985</ref>. | '''FGF''' signaling is important in the pathogenesis of a variety of tumor types<ref>PMID:20094046</ref>, angiogenesis<ref>PMID:7542215</ref> and wound healing<ref>PMID:12696985</ref>. '''FGF1''' is a potentially safw candidate for restoring euglycaemia without causing a=overt adverse effects<ref>PMID:28664920</ref>. Overexpression of the high molecular weight isoform of '''FGF2''' in bone results in catabolic activity in joint cartilage and bone that leads to osteoarthropathy<ref>PMID:27732085</ref>. | ||
== Structural insights == | == Structural insights == | ||
