6b11: Difference between revisions
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==TylHI in complex with native substrate 23-deoxy-5-O-mycaminosyl-tylonolide (23-DMTL)== | |||
<StructureSection load='6b11' size='340' side='right' caption='[[6b11]], [[Resolution|resolution]] 1.99Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6b11]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B11 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B11 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CGM:(4R,5S,6S,7R,9R,11E,13E,15S,16R)-16-ethyl-4-hydroxy-5,9,13,15-tetramethyl-2,10-dioxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11,13-dien-6-yl+3,6-dideoxy-3-(dimethylamino)-beta-D-glucopyranoside'>CGM</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr> | |||
[[Category: | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr> | ||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/20-oxo-5-O-mycaminosyltylactone_23-monooxygenase 20-oxo-5-O-mycaminosyltylactone 23-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.15.34 1.14.15.34] </span></td></tr> | ||
[[Category: Podust, L | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b11 OCA], [http://pdbe.org/6b11 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b11 RCSB], [http://www.ebi.ac.uk/pdbsum/6b11 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b11 ProSAT]</span></td></tr> | ||
[[Category: Sherman, D | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/TYLH1_STRFR TYLH1_STRFR]] Involved in the biosynthesis of the complex macrolide antibiotic tylosin. Catalyzes the hydroxylation of 20-oxo-5-O-beta-mycaminosyltylactone at the C-23 position to yield 5-O-beta-mycaminosyltylonolide.<ref>PMID:7283418</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: 20-oxo-5-O-mycaminosyltylactone 23-monooxygenase]] | |||
[[Category: DeMars, M D]] | |||
[[Category: Podust, L M]] | |||
[[Category: Sherman, D H]] | |||
[[Category: Oxidoreductase]] | |||
[[Category: P450]] | |||
[[Category: Tylosin biosynthesis]] | |||
Revision as of 08:16, 19 December 2018
TylHI in complex with native substrate 23-deoxy-5-O-mycaminosyl-tylonolide (23-DMTL)
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