Arginase

spinqualitylabelsall models Structure of rat arginase containing Mn+2 (purple) complex with ornithine (cyan) and urea (yellow) (PDB code 1hqg). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Arginase (Arg) catalyzes the conversion of arginine to ornithine and urea. Arg is the final enzyme in the urea cycle. Arg requires 2 manganese ions for functioning. Disease Arg deficiency is an inherited disorder causing the accumulation of toxic urea in the blood. Structural highlights The manganese ions are located at the bottom of a 15A cleft. Active site. The proposed reaction mechanism involves H141, D128, E277 in rat. 3D structures of arginase Arginase 3D structures

3D structures of arginase

Updated on 19-March-2019

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• Arginase
  • Arginase 3D structures – hArg 1 - human
    
  • 2ef4, 2ef5, 2eiv – Arg – Thermus thermophilus
    
  • 4rhi, 4rhj, 4rhk – TbArg – Trypanosoma brucei
    
  • 5ynl – Arg – Glaciozyma antarctica
    
• Mn containing arginase
  • 1rla, 2rla – rArg + Mn – rat
    
  • 3rla, 4rla, 5rla, 1hqx, 1p8m, 1p8n, 1p8o, 1p8p, 1p8q, 1p8r, 1p8s, 1ta1, 1tbh, 1tbj, 1tbl, 3e8q, 3e8z – rArg (mutant) + Mn
    
  • 1wva, 2pha, 2zav – hArg 1 + Mn
    
  • 1wvb – hArg 1 (mutant) + Mn
    
  • 1cev, 2cev – BcArg + Mn – Bacillus caldovelox
    
  • 6dkt – BsArg + Mn – Bacillus subtilis
    
  • 6nbk – Arg + Mn – Bacillus cereus
    
  • 4g3h – Arg + Mn – Helicobacter pylori
    
  • 4ity – LmArg + Mn – Leishmania mexicana
    
  • 4q3p – SmArg + Mn – Schistosoma mansoni
    
  • 4rhl, 4rhm, 4rhq – TbArg (mutant) + Mn
    
• Mn containing arginase complexes
  • 1d3v, 1hq5 – rArg + Mn + Arg analog
    
  • 1hqf, 1hqh – rArg + Mn + hydroxyl-Arg
    
  • 1hqg – rArg (mutant) + Mn + ornithine + urea
    
  • 1r1o, 1t4p, 1t4r, 1t4t, 1t5f – rArg + Mn + inhibior
    
  • 1t4s – rArg + Mn + valine
    
  • 1t5g – rArg + Mn + Arg
    
  • 1zpe, 1zpg – rArg (mutant) + Mn + alkylamine derivative
    
  • 3e9b – rArg (mutant) + Mn + Br-ethyl cysteine
    
  • 2aeb, 2pll – hArg 1 + Mn + Arg analog
    
  • 2pho – hArg 1 + Mn + thiosemicarbazide
    
  • 3dj8 – hArg 1 + Mn + amino-epoxy octanoic acid
    
  • 3e6k, 3e6v – hArg 1 (mutant) + Mn + Arg analog
    
  • 3f80 – hArg 1 + Mn + nitro-norleucine
    
  • 3kv2, 3lp7 – hArg 1 + Mn + nor-ω-hydroxy-Arg
    
  • 3gmz – hArg 1 + Mn + ornithine
    
  • 3gn0 – hArg 1 + Mn + ornithine derivative
    
  • 3lp4 – hArg 1 + Mn + lysine
    
  • 3mfv, 3mfw – hArg 1 + Mn + histidine derivative
    
  • 3mjl – hArg 1 + Mn + amino-imidazole
    
  • 3sjt, 3skk, 4hww, 4hxq, 4ie1 – hArg 1 + Mn + inhibitor
    
  • 4fci – hArg 1 + Mn + amino-guanidino propionate
    
  • 3cev – BcArg + Mn + Arg
    
  • 5cev – BcArg + Mn + Lys
    
  • 4iu0, 4iu1, 4iu4, 5hj9, 5hja – LmArg + Mn + inhibitor
    
  • 4iu5 – LmArg + Mn + ornithine
    
  • 4q3q, 4q3r, 4q3s, 4q3t, 4q3u, 4q3v – SmArg + Mn + inhibitor
    
  • 4q40, 4q41 – SmArg + Mn + amino acid
    
  • 4q42 – SmArg + Mn + ornithine
    
  • 4cev – Arg + Mn + ornithine – Bacillus caldovelox
    
  • 3mmr, 3sl0, 3sl1 – Arg + Mn + borohexanoate derivative – Plasmodium falciparium
    
• Co containing arginase
  • 3th7, 3the – hArg 1 + Co
    
  • 3thh – hArg 1 + Co + Arg analog
    
  • 3thj – hArg 1 + Co + ornithine
    
  • 4fck – hArg 1 + Co + amino-guanidino propionate
    
• Ni containing arginase
  • 4gsm – hArg 1 + Ni
    
  • 4gsv – hArg 1 + Ni + Arg analog
    
• Zn containing arginase
  • 4gsz – hArg 1 + Zn + Arg analog
    
• Mg containing arginase
  • 6nfp – BsArg + Mg
    
• Mn and Zn containing arginase
  • 4gwc – hArg 1 + Mn + Zn
    
  • 4gwd – hArg 1 + Mn + Zn + Arg analog
    
• Arginase 2
  • 1pq3 – hArg 2+ Mn
    
  • 4hze, 4i06, 4ie2, 4ie3, 4ixu, 4ixv – hArg 2 + Mn + inhibitor
    

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Michal Harel, Alexander Berchansky