CD8: Difference between revisions
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'''CD8''' (or '''Cluster of Differentiation 8''') is a T-cell co-receptor. CD8 binds to class I MHC protein. CD8 exists as 2 isoforms: α and β. CD8 forms a dimer of CD8α and CD8β. The extracellular domain of CD8 has immunoglobulin variable-like conformation. This domain of CD8α interacts with α3 domain of class I MHC enhancing the binding of the T-cell receptor and the target cell.<ref>PMID:9916707</ref> | '''CD8''' (or '''Cluster of Differentiation 8''') is a T-cell co-receptor. CD8 binds to class I MHC protein. CD8 exists as 2 isoforms: α and β. CD8 forms a dimer of CD8α and CD8β. The extracellular domain of CD8 has immunoglobulin variable-like conformation. This domain of CD8α interacts with α3 domain of class I MHC enhancing the binding of the T-cell receptor and the target cell.<ref>PMID:9916707</ref> | ||
*<scene name='55/551462/Cv/2'>CD8α, CD8β and antibody</scene> ([[3b9k]]).<ref>PMID:18929574</ref> | *<scene name='55/551462/Cv/2'>CD8α, CD8β and antibody</scene> ([[3b9k]]).<ref>PMID:18929574</ref> | ||
== 3D Structures of CD8 == | |||
[[CD8 3D structures]] | |||
</StructureSection> | </StructureSection> | ||
== 3D Structures of CD8 == | == 3D Structures of CD8 == | ||
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**[[2q3a]] – CD8 extracellular domain – rhesus monkey <BR /> | **[[2q3a]] – CD8 extracellular domain – rhesus monkey <BR /> | ||
**[[5edx]] – CD8 extracellular domain – pig <BR /> | **[[5edx]] – CD8 extracellular domain – pig <BR /> | ||
**[[5z11]] – CD8 extracellular domain – carp <BR /> | |||
*CD8α complex | *CD8α complex | ||
