Colony-stimulating factor

spinqualitylabelsall models Glycosylated human macrophage colony-stimulating factor (deeppink and salmon) complex with macrophage colony-stimulating factor 1 receptor (deepskyblue and green) (PDB code 4wrl) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Colony-stimulating factors (CSF) are growth regulatory factors which influence functional activity, survival, proliferation and differentiation of myeloid mature and haemopoietic cells. Four distinct CSFs were characterized. Granulocyte colony-stimulating factor (G-CSF) acts on proliferation, functional stimulation and differentiation of progenitors of neutrophils. Granulocyte-macrophage colony-stimulating factor (GM-CSF) acts on proliferation, functional stimulation and differentiation of progenitors of neutrophils, monocytes and granulocytes. Macrophage colony-stimulating factor (M-CSF) or lanimostin acts on proliferation, functional stimulation and differentiation of progenitors of monocytes and macrophages. multi-colony-stimulating factor also known as interleukin 3. Relevance Depletion of CSFs have therapeutic benefit in many inflammatory and autoimmune conditions. G-CSF and GM-CSF are used to increase low white blood cell levels in cancer patients following chemotherapy and to release haematopoietic stem cells which replace bone marrow cells after anti-cancer treatments. G-CSF is a neurotrophic factor and thus a candidate for the treatment of neurodegenerative conditions. G-CSF and GN-CSF ar commercially available for clinical use. Structural highlights The structure of the complex between M-CSF and its receptor shows that a dimer of M-CSF binds to 2 molecules of the receptor. There are two binding sites between the molecules designated site I and site II. All interactions. 3D structures of colony-stimulating factor Colony-stimulating factor 3D structures

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky