6qgk: Difference between revisions
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==Structure of human Bcl-2 in complex with THIQ-phenyl pyrazole compound== | |||
<StructureSection load='6qgk' size='340' side='right'caption='[[6qgk]], [[Resolution|resolution]] 1.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6qgk]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QGK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QGK FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=J1Q:1-[2-[[(3~{S})-3-(aminomethyl)-3,4-dihydro-1~{H}-isoquinolin-2-yl]carbonyl]phenyl]-~{N},~{N}-dibutyl-5-methyl-pyrazole-3-carboxamide'>J1Q</scene></td></tr> | |||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6qg8|6qg8]], [[6qgg|6qgg]], [[6qgh|6qgh]], [[6qgj|6qgj]]</td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qgk OCA], [http://pdbe.org/6qgk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qgk RCSB], [http://www.ebi.ac.uk/pdbsum/6qgk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qgk ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN]] Note=A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN]] Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).<ref>PMID:18570871</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Casara, P]] | |||
[[Category: Chen, I]] | [[Category: Chen, I]] | ||
[[Category: Davidson, J]] | [[Category: Davidson, J]] | ||
[[Category: Davis, B]] | [[Category: Davis, B]] | ||
[[Category: Diguarher, T Le]] | |||
[[Category: Dokurno, P]] | |||
[[Category: Geneste, O]] | |||
[[Category: Graham, C J]] | |||
[[Category: Harris, R]] | |||
[[Category: Hickman, J]] | [[Category: Hickman, J]] | ||
[[Category: Hubbard, R E]] | |||
[[Category: Jordan, A M]] | |||
[[Category: Kotschy, A]] | |||
[[Category: Matassova, N]] | |||
[[Category: Murray, J]] | |||
[[Category: Pedder, C]] | |||
[[Category: Ray, S]] | |||
[[Category: Roughley, S]] | |||
[[Category: Smith, J]] | |||
[[Category: Stark, J]] | [[Category: Stark, J]] | ||
[[Category: Walmsley, C]] | |||
[[Category: Wang, Y]] | |||
[[Category: Whitehead, N]] | [[Category: Whitehead, N]] | ||
[[Category: | [[Category: Williamson, D S]] | ||
[[Category: Apoptosis]] | |||
[[Category: Bcl2]] | |||
[[Category: | [[Category: Drug design]] | ||
[[Category: | [[Category: Small molecule inhibitor]] | ||
[[Category: | |||
[[Category: | |||
Latest revision as of 05:46, 12 June 2019
Structure of human Bcl-2 in complex with THIQ-phenyl pyrazole compound
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Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Large Structures
- Casara, P
- Chen, I
- Davidson, J
- Davis, B
- Diguarher, T Le
- Dokurno, P
- Geneste, O
- Graham, C J
- Harris, R
- Hickman, J
- Hubbard, R E
- Jordan, A M
- Kotschy, A
- Matassova, N
- Murray, J
- Pedder, C
- Ray, S
- Roughley, S
- Smith, J
- Stark, J
- Walmsley, C
- Wang, Y
- Whitehead, N
- Williamson, D S
- Apoptosis
- Bcl2
- Drug design
- Small molecule inhibitor
