Maltose-binding protein

spinqualitylabelsall models E. coli maltose-binding protein complex with maltose (PDB entry 1anf) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Maltose-binding protein (MBP) or ABC maltose transporter is part of the maltose/maltodextrin system in E. coli which is responsible of the catabolism of maltodextrin. MBP binds maltodextrin when the latter diffuses into the periplasm and passes it to proteins involved in active transport. Relevance MBP is widely used in molecular biology as it adds to the solubility of the proteins expressed in E. coli by being fused to them. The MBP-fusion protein can be purified by binding it to an amylose column followed by elution with maltose. Structural highlights The MBP sugar binding cleft is rich with protein-ligand hydrogen bonds. Water molecules are shown as red spheres.

3D structures of maltose-binding protein

Updated on 09-July-2019

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• MBP
  • 1llx, 1jw4, 1lls, 1omp - MBP
    
  • 3sey, 3sex, 3sew, 3sev, 3seu, 3set, 3ses, 3ser, 2v93, 1zkb, 1n3x, 1peb , 1mpc, 3kjt, 1mdp, 1mdq - MBP (mutant)
    
  • 2klf, 2d21 – MBP – NMR
    
  • 1ziu – MBP (mutant) + Ni
    
  • 1zjl – MBP (mutant) + Zn
    
  • 1zmg - MBP (mutant) + Cu
    
  • 4log - MBP /nuclear receptor
    
  • 4ogm - MBP /pilin
    
  • 4pe2 - MBP /pilA1
    
  • 4khz - MBP MalK, MalF, MalG, MBP
    
  • 3fh6 - MBP MalK, MalF, MalG
    
  • 2xd2 – SpMBP – Streptococcus pneumoniae
• MBP complex with saccharide
  • 1n3w, 1nl5, 1mpd, 1iud, 1jvx, 1jvy - MBP (mutant) + maltose
    
  • 1anf, 1jw5, 2xz3 - MBP + maltose
    
  • 3mbp - MBP + maltotriose
    
  • 4mbp - MBP + maltotetrose
    
  • 1ez9 - MBP + maltodextrin
    
  • 3hpi – MBP (mutant) + sucrose
    
  • 1lax - MBP (mutant) + glucose
    
  • 2h25, 1ezo, 1dmb - MBP + β-cyclodextrin
    
  • 1ezp - MBP (mutant) + β-cyclodextrin
    
  • 1fqa, 1fqb, 1fqc, 1fqd - MBP + maltotetraitol
    
  • 3puy, 3puz - MBP MalK, MalF, MalG, MBP + maltose + AMPPNP
    
  • 3rlf - MBP MalK, MalF, MalG, MBP + maltose + AMPPNP
    
  • 4jbw - MBP MalK, MalF, MalG + EIIAGLC
    
  • 3pv0 - MBP MalK, MalF, MalG, MBP + maltose
    
  • 2r6g, 3puv, 3puw, 3pux, 4ki0 - MBP MalK, MalF, MalG, MBP + maltose + nucleotide
    
  • 3ob4 - MBP AraH2 (mutant) + maltotriose
    
  • 1elj – MBP + glucose – Pyrococcus furiosus
    
  • 3jyr – MBP + α-acarbose – Salmonella enterica
    
  • 2xd3 – SpMBP + maltopentaose
• MBP complex with protein
  • 3pgf – MBP (mutant) + synthetic antigen binder
    
  • 2r6g, 4khz, 4ki0 - MBP + maltose transporter complex
    
  • 3puv, 3puw, 3pux – MBP + maltose transporter complex + ADP
    
  • 3rlf - MBP + maltose transporter complex + Mg-AMPPNP
    
  • 1svx – MBP + ankyrin repeat protein OFF7
    
  • 1nmu - MBP + ribosomal protein L30
    
  • 1t0k - MBP + ribosomal protein L30 + RNA
    
  • 3rum – MBP + ristocetin
    
  • 4nuf - MBP /nuclear receptor + orphan nuclear receptor peptide
    
  • 5ldf - MBP + glutamine synthetase
    
  • 5jtr, 5jtq - MBP + SecB
    
  • 5gs2 - MBP + anti-MBP + anti-repebody + repebody
    
  • 5gru - MBP + diabody protein
    
  • 5m15, 5m14, 5m13 - MBP + nanobody
    
  • 5bk2, 5bk1, 5bjz - MBP + antibody
    
  • 5fio, 5aq9 - MBP + darpin
    
  • 5lem, 5lel - MBP + GFP + darpin
    
  • 5e24 - MBP + protein hairless + suppressor of hairless protein + DNA
    
  • 5cl1 - MBP + frizzled 4
    
  • 5cbn - MBP + MBP3-16
    
  • 4wjv - MBP + ribosome assembly protein + ribosome biogenesis protein
    

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Michal Harel, Alexander Berchansky