6plf: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6plf is ~~ON HOLD~~

==Crystal structure of human PHGDH complexed with Compound 1==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6plf]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PLF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PLF FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ONV:4-{(1S)-1-[(5-chloro-6-{[(5S)-2-oxo-1,3-oxazolidin-5-yl]methoxy}-1H-indole-2-carbonyl)amino]-2-hydroxyethyl}benzoic+acid'>ONV</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6plf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6plf OCA], [http://pdbe.org/6plf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6plf RCSB], [http://www.ebi.ac.uk/pdbsum/6plf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6plf ProSAT]</span></td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/SERA_HUMAN SERA_HUMAN]] Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency (PHGDH deficiency) [MIM:[http://omim.org/entry/601815 601815]]. It is characterized by congenital microcephaly, psychomotor retardation, and seizures.

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Lakshminarasimhan, D]]

[[Category: Olland, A]]

[[Category: Suto, R K]]

[[Category: White, A]]

[[Category: Dehydrogenase]]

[[Category: Oxidoreductase]]

[[Category: Oxidoreductase-inhibitor complex]]

[[Category: Serine metabolism]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6plf is ON HOLD
+==Crystal structure of human PHGDH complexed with Compound 1==
+<StructureSection load='6plf' size='340' side='right'caption='[[6plf]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6plf]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PLF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PLF FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ONV:4-{(1S)-1-[(5-chloro-6-{[(5S)-2-oxo-1,3-oxazolidin-5-yl]methoxy}-1H-indole-2-carbonyl)amino]-2-hydroxyethyl}benzoic+acid'>ONV</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6plf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6plf OCA], [http://pdbe.org/6plf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6plf RCSB], [http://www.ebi.ac.uk/pdbsum/6plf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6plf ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/SERA_HUMAN SERA_HUMAN]] Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency (PHGDH deficiency) [MIM:[http://omim.org/entry/601815 601815]]. It is characterized by congenital microcephaly, psychomotor retardation, and seizures.
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Lakshminarasimhan, D]]
+[[Category: Olland, A]]
+[[Category: Suto, R K]]
+[[Category: White, A]]
+[[Category: Dehydrogenase]]
+[[Category: Oxidoreductase]]
+[[Category: Oxidoreductase-inhibitor complex]]
+[[Category: Serine metabolism]]