3f5c

Structure of Dax-1:LRH-1 complex

spinqualitylabelsall models 3f5c, resolution 3.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3f5c is a 3 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Gene: Nr5a2, Lrh1 (LK3 transgenic mice), Nr0b1, Ahch, Dax1 (LK3 transgenic mice) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [NR5A2_MOUSE] Binds to promoters containing the sequence element 5'-AACGACCGACCTTGAG-3'. Plays a role in the regulation of gene expression in liver and pancreas. May play a role in embryonic development (By similarity). [NR0B1_MOUSE] Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). Publication Abstract from PubMed The Dax-1 protein is an enigmatic nuclear receptor that lacks an expected DNA binding domain, yet functions as a potent corepressor of nuclear receptors. Here we report the structure of Dax-1 bound to one of its targets, liver receptor homolog 1 (LRH-1). Unexpectedly, Dax-1 binds to LRH-1 using a new module, a repressor helix built from a family conserved sequence motif, PCFXXLP. Mutations in this repressor helix that are linked with human endocrine disorders dissociate the complex and attenuate Dax-1 function. The structure of the Dax-1:LRH-1 complex provides the molecular mechanism for the function of Dax-1 as a potent transcriptional repressor. The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1.,Sablin EP, Woods A, Krylova IN, Hwang P, Ingraham HA, Fletterick RJ Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18390-5. Epub 2008 Nov 17. PMID:19015525 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Liver receptor homolog-1

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