6ee1: Difference between revisions
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==Crystal structure of Mycobacterium tuberculosis ICL2 in complex with acetyl-CoA== | |||
<StructureSection load='6ee1' size='340' side='right'caption='[[6ee1]], [[Resolution|resolution]] 2.36Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6ee1]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EE1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EE1 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6edw|6edw]], [[6edz|6edz]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Isocitrate_lyase Isocitrate lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.3.1 4.1.3.1] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ee1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ee1 OCA], [http://pdbe.org/6ee1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ee1 RCSB], [http://www.ebi.ac.uk/pdbsum/6ee1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ee1 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/ACEA2_MYCTO ACEA2_MYCTO]] Involved in the persistence and virulence of M.tuberculosis. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates.<ref>PMID:10572116</ref> <ref>PMID:15895072</ref> <ref>PMID:16879647</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Isocitrate lyase]] | |||
[[Category: Large Structures]] | |||
[[Category: Bashiri, G]] | [[Category: Bashiri, G]] | ||
[[Category: Bhusal, R]] | |||
[[Category: Leung, I]] | [[Category: Leung, I]] | ||
[[Category: | [[Category: Lyase]] | ||
Revision as of 16:27, 14 August 2019
Crystal structure of Mycobacterium tuberculosis ICL2 in complex with acetyl-CoA
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