Matriptase: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
ST14 active site has the conformation of a typical serine protease like trypsin or chymotrypsin with the <scene name='59/595760/Cv/5'>Ser-His-Asp catalytic triad</scene> and <scene name='59/595760/Cv/6'>Gly-Ser oxyanion hole</scene>. The <scene name='59/595760/Cv/7'>inhibitor benzamidine blocks the catalytic triad</scene><ref>PMID:11696548</ref>. Water molecules shown as red spheres. | ST14 active site has the conformation of a typical serine protease like trypsin or chymotrypsin with the <scene name='59/595760/Cv/5'>Ser-His-Asp catalytic triad</scene> and <scene name='59/595760/Cv/6'>Gly-Ser oxyanion hole</scene>. The <scene name='59/595760/Cv/7'>inhibitor benzamidine blocks the catalytic triad</scene><ref>PMID:11696548</ref>. Water molecules shown as red spheres. | ||
== 3D Structures of matriptase == | |||
[[Matriptase 3D structures]] | |||
</StructureSection> | </StructureSection> | ||
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*'''matriptase''' | *'''matriptase''' | ||
**[[4is5]] – hST14 catalytic domain - human<br /> | **[[4is5]], [[5lyo]] – hST14 catalytic domain - human<br /> | ||
*Matriptase complex with small molecule inhibitor | *Matriptase complex with small molecule inhibitor | ||
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**[[4o97]], [[4o9v]] – hST14 catalytic domain + benzamidine derivative + tetrapeptide<br /> | **[[4o97]], [[4o9v]] – hST14 catalytic domain + benzamidine derivative + tetrapeptide<br /> | ||
**[[3ncl]] – hST14 catalytic domain (mutant) + benzamidine derivative<br /> | **[[3ncl]] – hST14 catalytic domain (mutant) + benzamidine derivative<br /> | ||
**[[2gv7]], [[4jz1]], [[4jzi]], [[4jyt]] – hST14 catalytic domain + inhibitor<br /> | **[[2gv7]], [[4jz1]], [[4jzi]], [[4jyt]], [[4r0i]] – hST14 catalytic domain + inhibitor<br /> | ||
**[[6n4t]] – hST14 catalytic domain + benzothiazole derivative<br /> | |||
*Matriptase complex with polypeptide inhibitor | *Matriptase complex with polypeptide inhibitor | ||
