Nonstructural protein

spinqualitylabelsall models Hepatitis virus nonstructural protein complex with non-nucleoside analogue inhibitor (PDB entry 1nhu) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Nonstructural protein (NS) is a protein encoded by a virus which is not part of the viral particle. Pestivirus encode a NS at the N-terminal of their polyproteins (Npro). For homology model and multiple sequence alignment see User:Michael Strong/H1N1/NS User:Michael Strong/H1N1/NS1/MSA User:Michael Strong/H1N1/NS2/MSA Student Project 4 for UMass Chemistry 423 Spring 2015. Structural highlights Hepatitis virus NS active site shows hydrogen bond interactions and hydrophobic pocket interactions. 3D Structures of Nonstructural protein Nonstructural protein 3D structures

3D Structures of Nonstructural protein

Updated on 11-November-2019

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• Nonstructural protein
  • 3o9q, 4opa, 4oph – IvNS1 (mutant) – Influenza virus
    
  • Student Project 4 for UMass Chemistry 423 Spring 2015, Nonstructural protein 3D structures, 3o9t, 3o9u, 3f5t – IvNS1
    
  • 3m8a, 2z0a, 1xeq, 1ail – IvNS1 RNA-binding domain
    
  • 3p31 – IvNS1 C terminal effector domain
    
  • 3p38, 3p39 – IvNS1 C terminal effector domain (mutant)
    
  • 1ns1 - IvNS1 RNA-binding domain - NMR
    
  • 3m5r, 2gx9 - IvNS1 effector domain
    
  • 1pd3 – IvNS2 M1-binding domain
    
  • 3l6p, 3lkw – DvNS2B/3 protease domain (mutant) – Dengue virus
    
  • 4r05 – DvNS5 residues 2491-2752
    
  • 2o1j – RvNSP4 diarrhea-inducing domain – human rotavirus
    
  • 2gu0 – RvNS2
    
  • 5y2h, 5y2j, 5y9r – NSP4 diarrhea-inducing domain – bovine rotavirus
    
  • 2ajj, 2ajm, 2ajn, 2ajo – NS5A membrane-anchor domain – bovine viral diarrhea virus – NMR
    
  • 1fw5 – NSP1 membrane-binding domain – Semliki forest virus – NMR
    
  • 5vj2 – NS1 – respiratory syncytial virus
    
  • 5i65 – NS ORF1A – porcine reproductive and respiratory syndrome virus
    
  • 1qol – NSP20A (mutant) - Foot-and-mouth disease virus
    
  • 1nhu – HvNS5B RNA-dependent RNA polymerase residues 2420-2989 – Hepatitis C virus
    
  • 1r7c, 1r7d, 1r7e, 1r7f, 1r7g - HvNS5A membrane-anchor domain - NMR
    
  • 2gdt, 2hsx – SvNS1 (mutant) – Sars coronavirus – NMR
    
  • 2jzd, 2jze, 2jzf, 2rnk – SvNS3 residues 527-651 – NMR
    
  • 2kaf - SvNS3 residues 1473-1532 – NMR
    
  • 2kys – SvNS7 – NMR
    
  • 2l8k – NS7 residues 1454-1575 – NMR
    
  • 3mtv – NS1 residues 181-383 – PRRS virus
    
  • 3zfn, 3zfo, 3zfq, 3zfp, 3zfr, 3zft, 3zfu – Npro (mutant) – Pestivirus
    
  • 4x2z – NS3 residues 1174-1483 – Avian infectious bronchitis virus
    
• Nonstructural protein binary complex
  • 2xbm – DvNS5 methyltransferase domain + RNA
    
  • 3p8z - DvNS5 methyltransferase domain + SAH + inhibitor
    
  • 5cuq - DvNS5 methyltransferase domain + inhibitor
    
  • 5fc8 - DvNS5 C-terminal + importin
    
  • 2hye – SvNSV + DNA damage-binding protein + cullin-4A + ring-box protein – Simian virus 5
    
  • 2b5l - SvNSV + DNA damage-binding protein
    
  • 1nhv, 1nhu – HvNS5B RNA-dependent RNA polymerase residues 2420-2989 + inhibitor
    
  • 1dxp, 1dy8, 1dy9, 1w3c – HvNS4A + HvHelicase NS3
    
  • 4k8b - HvNS4A + HvProtease NS3 + inhibitor
    
  • 4a1t, 4a1x - HvNS4A + peptide inhibitor
    
  • 3phe – HvNS5B + quinolone derivative
    
  • 3ub0 – NSP6 + NSP7 – Feline infectious peritonitis virus
    
  • 1knz – RvNSP34 N terminal + mRNA
    
  • 1lj2 – RvNSP34 C terminal + eukaryotic protein synthesis initiation factor peptide
    
  • 4r8r – DvNS5 residues 2491-2752 + adenosyl-Met
    
  • 4r8s – DvNS5 residues 2491-2752 + sinefungin
    

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