5qip: Difference between revisions

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'''Unreleased structure'''


The entry 5qip is ON HOLD
==Covalent fragment group deposition -- Crystal Structure of OUTB2 in complex with PCM-0102153==
 
<StructureSection load='5qip' size='340' side='right'caption='[[5qip]], [[Resolution|resolution]] 1.63&Aring;' scene=''>
Authors: Sethi, R., Douangamath, A., Resnick, E., Bradley, A.R., Collins, P., Brandao-Neto, J., Talon, R., Krojer, T., Bountra, C., Arrowsmith, C.H., Edwards, A., London, N., von Delft, F.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5qip]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QIP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5QIP FirstGlance]. <br>
Description: Covalent fragment group deposition --Crystal Structure of OUTB2 in complex with PCM-0102153
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=J51:benzyl+acetylcarbamate'>J51</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitinyl_hydrolase_1 Ubiquitinyl hydrolase 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.12 3.4.19.12] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5qip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qip OCA], [http://pdbe.org/5qip PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5qip RCSB], [http://www.ebi.ac.uk/pdbsum/5qip PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5qip ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/OTUB2_HUMAN OTUB2_HUMAN]] Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains.<ref>PMID:12704427</ref> <ref>PMID:18954305</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Ubiquitinyl hydrolase 1]]
[[Category: Arrowsmith, C H]]
[[Category: Bountra, C]]
[[Category: Bradley, A R]]
[[Category: Brandao-Neto, J]]
[[Category: Collins, P]]
[[Category: Collins, P]]
[[Category: Bradley, A.R]]
[[Category: Delft, F von]]
[[Category: Arrowsmith, C.H]]
[[Category: Douangamath, A]]
[[Category: Talon, R]]
[[Category: Brandao-Neto, J]]
[[Category: Edwards, A]]
[[Category: Edwards, A]]
[[Category: Douangamath, A]]
[[Category: Krojer, T]]
[[Category: Krojer, T]]
[[Category: London, N]]
[[Category: Resnick, E]]
[[Category: Resnick, E]]
[[Category: Von Delft, F]]
[[Category: Sethi, R]]
[[Category: Sethi, R]]
[[Category: Bountra, C]]
[[Category: Talon, R]]
[[Category: London, N]]
[[Category: Deubiquitinating enzyme otub2]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Protease otub2]]
[[Category: Sgc - diamond i04-1 fragment screening]]
[[Category: Xchemexplorer]]
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