Im7: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| Line 1: | Line 1: | ||
Im7 is a [[Colicin Immunity Protein]] that binds to the nuclease domain of [[Colicin E7]], in order to protect the cell producing the [[Colicin]] from the [[DNase Activity]]. When it binds to colicin E7 it physically blocks off the major dsDNA binding sites<ref> PMID: 14962381 </ref>. | Im7 is a [[Colicin Immunity Protein]] that binds to the nuclease domain of [[Colicin E7]], in order to protect the cell producing the [[Colicin]] from the [[DNase Activity]]. When it binds to colicin E7 it physically blocks off the major dsDNA binding sites<ref> PMID: 14962381 </ref>. | ||
<Structure load='7cei' size='350' frame='true' align='right' caption='' /> | <Structure load='7cei' size='350' frame='true' align='right' caption='Im7 (grey) complex with colicin E7 (green) and Zn+2 ion (grey) (PDB code 7cei]])' /> | ||
This structure shows the <scene name='Im7/Im7/1'>Immunity protein</scene> bound to the <scene name='Im7/Cole7c/1'>ColE7 cytotoxic domain</scene>. | This structure shows the <scene name='Im7/Im7/1'>Immunity protein</scene> bound to the <scene name='Im7/Cole7c/1'>ColE7 cytotoxic domain</scene>. | ||
Revision as of 10:46, 12 January 2020
Im7 is a Colicin Immunity Protein that binds to the nuclease domain of Colicin E7, in order to protect the cell producing the Colicin from the DNase Activity. When it binds to colicin E7 it physically blocks off the major dsDNA binding sites[1].
|
This structure shows the Immunity protein bound to the ColE7 cytotoxic domain.
- ↑ Hsia KC, Chak KF, Liang PH, Cheng YS, Ku WY, Yuan HS. DNA binding and degradation by the HNH protein ColE7. Structure. 2004 Feb;12(2):205-14. PMID:14962381 doi:10.1016/j.str.2004.01.004
