Subtilisin: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
The active site of Sub contains the <scene name='43/430882/Cv/12'>catalytic triad: Ser-His-Asp</scene>. The <scene name='43/430882/Cv/13'>peptide inhibitor has numerous interactions with Sub</scene> and the <scene name='43/430882/Cv/14'>scissile bond is flanked by Cys-Pro-Met-Val</scene><ref>PMID:1920411</ref>. | The active site of Sub contains the <scene name='43/430882/Cv/12'>catalytic triad: Ser-His-Asp</scene>. The <scene name='43/430882/Cv/13'>peptide inhibitor has numerous interactions with Sub</scene> and the <scene name='43/430882/Cv/14'>scissile bond is flanked by Cys-Pro-Met-Val</scene><ref>PMID:1920411</ref>. | ||
== 3D Structures of Subtilisin == | |||
[[Subtilisin 3D structures]] | |||
</StructureSection> | </StructureSection> | ||
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**[[2z2x]] – TkSub - ''Thermococcus kodakarensis''<br /> | **[[2z2x]] – TkSub - ''Thermococcus kodakarensis''<br /> | ||
**[[1sca]], [[1scb]], [[1sbc]], [[3unx]] – BsSub - ''Bacillus subtilis'' (Subtilisin Carlsberg)<br /> | **[[1sca]], [[1scb]], [[1sbc]], [[3unx]] – BsSub - ''Bacillus subtilis'' (Subtilisin Carlsberg)<br /> | ||
**[[6pak]] - BsSub E (mutant)<br /> | |||
**[[1pxq]] – BsSub - NMR<br /> | **[[1pxq]] – BsSub - NMR<br /> | ||
**[[1gns]], [[1sup]], [[1st2]], [[1s01]], [[1sbt]], [[2sbt]], [[2st1]] – BaSub - ''Bacillus amyloliquefaciens''<br /> | **[[1gns]], [[1sup]], [[1st2]], [[1s01]], [[1sbt]], [[2sbt]], [[2st1]] – BaSub - ''Bacillus amyloliquefaciens''<br /> | ||
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* Mature subtilisin complexed with its propeptide | * Mature subtilisin complexed with its propeptide | ||
**[[3cnq]] – BaSub<br /> | **[[3cnq]], [[5ox2]] – BaSub + prodomain<br /> | ||
**[[1spb]] – BaSub (mutant)<br /> | **[[1spb]] – BaSub (mutant) + prodomain<br /> | ||
**[[3a3n]], [[3a3o]], [[3a3p]], [[2z56]], [[2z57]], [[2z58]], [[2z2y]], [[2z30]] – TkSub<br /> | **[[3a3n]], [[3a3o]], [[3a3p]], [[2z56]], [[2z57]], [[2z58]], [[2z2y]], [[2z30]] – TkSub + prodomain<br /> | ||
**[[3vv2]] – TkSub (mutant)<br /> | **[[3vv2]] – TkSub (mutant) + prodomain<br /> | ||
**[[1scj]] – BsSub | **[[1scj]] – BsSub + prodomain<br /> | ||
* Subtilisin complexed with polypeptide inhibitor | * Subtilisin complexed with polypeptide inhibitor | ||
